Seroatlas · Human Serome Atlas

RTN4RL2

Reticulon-4 receptor-like 2

Also known as: NgR2, NGRH1, R4RL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86UN3
Gene
RTN4RL2
Ensembl
ENSG00000186907
Chromosome
11
Canonical length
420 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Enables signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway; corpus callosum development; and negative regulation of neuron projection development. Located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

420 residues, UniProt reviewed canonical sequence.

>Q86UN3|RTN4RL2
     1  MLPGLRRLLQ APASACLLLM LLALPLAAPS CPMLCTCYSS PPTVSCQANN FSSVPLSLPP
    61  STQRLFLQNN LIRTLRPGTF GSNLLTLWLF SNNLSTIYPG TFRHLQALEE LDLGDNRHLR
   121  SLEPDTFQGL ERLQSLHLYR CQLSSLPGNI FRGLVSLQYL YLQENSLLHL QDDLFADLAN
   181  LSHLFLHGNR LRLLTEHVFR GLGSLDRLLL HGNRLQGVHR AAFRGLSRLT ILYLFNNSLA
   241  SLPGEALADL PSLEFLRLNA NPWACDCRAR PLWAWFQRAR VSSSDVTCAT PPERQGRDLR
   301  ALREADFQAC PPAAPTRPGS RARGNSSSNH LYGVAEAGAP PADPSTLYRD LPAEDSRGRQ
   361  GGDAPTEDDY WGGYGGEDQR GEQMCPGAAC QAPPDSRGPA LSAGLPSPLL CLLLLVPHHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTN4RL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • liver: 38 nTPM
  • cerebral cortex: 34 nTPM
  • thyroid gland: 29 nTPM
  • amygdala: 17 nTPM
  • hippocampal formation: 16 nTPM
  • skin: 4.1 nTPM

Single-cell type

  • retinal bipolar cells: 25 nCPM
  • hepatocytes: 19 nCPM
  • late primary spermatocytes: 19 nCPM
  • brain excitatory neurons: 15 nCPM
  • oligodendrocyte progenitor cells: 12 nCPM
  • extravillous trophoblasts: 12 nCPM

Immune cell

  • myeloid DC: 1 nTPM
  • intermediate monocyte: 0.6 nTPM
  • classical monocyte: 0.3 nTPM
  • MAIT T-cell: 0.3 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • cerebral cortex: 116 nTPM
  • hippocampal formation: 86 nTPM
  • amygdala: 72 nTPM
  • basal ganglia: 61 nTPM
  • white matter: 50 nTPM
  • medulla oblongata: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.88
gnomAD missense Z
2.47
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RTN4RL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTN4RL2 as an antibody target. Whether an autoantibody or antibody against RTN4RL2 could matter depends on whether native RTN4RL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTN4RL2 is annotated at the cell surface, where native RTN4RL2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RTN4RL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RTN4RL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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