Seroatlas · Human Serome Atlas

LINGO3

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3

Also known as: LERN2, LIGO3_HUMAN, LRRN6B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C6S8
Gene: LINGO3
Ensembl: ENSG00000220008
Chromosome: 19
Canonical length: 592 aa
Protein class: Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

592 residues, UniProt reviewed canonical sequence.

>P0C6S8|LINGO3
     1  MTCWLCVLSL PLLLLPAAPP PAGGCPARCE CTVQTRAVAC TRRRLTAVPD GIPAETRLLE
    61  LSRNRIRCLN PGDLAALPAL EELDLSENAI AHVEPGAFAN LPRLRVLRLR GNQLKLIPPG
   121  VFTRLDNLTL LDLSENKLVI LLDYTFQDLH SLRRLEVGDN DLVFVSRRAF AGLLALEELT
   181  LERCNLTALS GESLGHLRSL GALRLRHLAI ASLEDQNFRR LPGLLHLEID NWPLLEEVAA
   241  GSLRGLNLTS LSVTHTNITA VPAAALRHQA HLTCLNLSHN PISTVPRGSF RDLVRLRELH
   301  LAGALLAVVE PQAFLGLRQI RLLNLSNNLL STLEESTFHS VNTLETLRVD GNPLACDCRL
   361  LWIVQRRKTL NFDGRLPACA TPAEVRGDAL RNLPDSVLFE YFVCRKPKIR ERRLQRVTAT
   421  AGEDVRFLCR AEGEPAPTVA WVTPQHRPVT ATSAGRARVL PGGTLEIQDA RPQDSGTYTC
   481  VASNAGGNDT YFATLTVRPE PAANRTPGEA HNETLAALRA PLDLTTILVS TAMGCITFLG
   541  VVLFCFVLLF VWSRGRGQHK NNFSVEYSFR KVDGPAAAAG QGGARKFNMK MI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LINGO3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 24 nTPM
cerebellum: 7.7 nTPM
spleen: 6 nTPM
hippocampal formation: 4.7 nTPM
small intestine: 4.7 nTPM
amygdala: 4.3 nTPM

Single-cell type

retinal bipolar cells: 168 nCPM
b-cells: 81 nCPM
neutrophils: 69 nCPM
thymocytes: 61 nCPM
breast myoepithelial cells: 44 nCPM
decidual stromal cells: 41 nCPM

Immune cell

eosinophil: 4 nTPM
neutrophil: 1.5 nTPM
basophil: 1.3 nTPM
naive B-cell: 0.4 nTPM
memory B-cell: 0.3 nTPM
T-reg: 0.3 nTPM

Brain region

basal ganglia: 85 nTPM
cerebellum: 30 nTPM
thalamus: 26 nTPM
medulla oblongata: 18 nTPM
cerebral cortex: 18 nTPM
amygdala: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0.01
gnomAD missense Z: 1.7
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

signaling receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LINGO3 as an antibody target. Whether an autoantibody or antibody against LINGO3 could matter depends on whether native LINGO3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LINGO3 is annotated at the cell surface, where native LINGO3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LINGO3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...