LRRC4C

Protein identityUniProt · HPA

UniProt accession

Q9HCJ2

Gene

LRRC4C

Ensembl

ENSG00000148948

Chromosome

11

Canonical length

640 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Cytosol

OverviewNCBI Gene

NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

640 residues, UniProt reviewed canonical sequence.

>Q9HCJ2|LRRC4C
     1  MLNKMTLHPQ QIMIGPRFNR ALFDPLLVVL LALQLLVVAG LVRAQTCPSV CSCSNQFSKV
    61  ICVRKNLREV PDGISTNTRL LNLHENQIQI IKVNSFKHLR HLEILQLSRN HIRTIEIGAF
   121  NGLANLNTLE LFDNRLTTIP NGAFVYLSKL KELWLRNNPI ESIPSYAFNR IPSLRRLDLG
   181  ELKRLSYISE GAFEGLSNLR YLNLAMCNLR EIPNLTPLIK LDELDLSGNH LSAIRPGSFQ
   241  GLMHLQKLWM IQSQIQVIER NAFDNLQSLV EINLAHNNLT LLPHDLFTPL HHLERIHLHH
   301  NPWNCNCDIL WLSWWIKDMA PSNTACCARC NTPPNLKGRY IGELDQNYFT CYAPVIVEPP
   361  ADLNVTEGMA AELKCRASTS LTSVSWITPN GTVMTHGAYK VRIAVLSDGT LNFTNVTVQD
   421  TGMYTCMVSN SVGNTTASAT LNVTAATTTP FSYFSTVTVE TMEPSQDEAR TTDNNVGPTP
   481  VVDWETTNVT TSLTPQSTRS TEKTFTIPVT DINSGIPGID EVMKTTKIII GCFVAITLMA
   541  AVMLVIFYKM RKQHHRQNHH APTRTVEIIN VDDEITGDTP MESHLPMPAI EHEHLNHYNS
   601  YKSPFNHTTT VNTINSIHSS VHEPLLIRMN SKDNVQETQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC4C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

19 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.31

gnomAD pLI

0.97

gnomAD missense Z

2.52

DepMap mean gene effect

0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• modulation of chemical synaptic transmission
• regulation of axonogenesis
• synaptic membrane adhesion

Molecular functions

• cell adhesion molecule binding
• cell-cell adhesion mediator activity

Cellular components

• extracellular space
• glutamatergic synapse
• membrane
• plasma membrane
• postsynaptic density membrane
• Schaffer collateral - CA1 synapse

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat N-terminal domain
• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Immunoglobulin I-set
• Immunoglobulin V-set domain
• Immunoglobulin-like fold
• Leucine-rich repeat domain superfamily
• Immunoglobulin-like domain superfamily
• Leucine-rich repeat and transmembrane domain-containing protein
• Leucine Rich Repeat
• Immunoglobulin I-set domain
• Leucine rich repeat

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Immunoglobulin domain
• Leucine-rich repeat
• Membrane
• Phosphoprotein
• Postsynaptic cell membrane
• Repeat
• Signal
• Synapse
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of LRRC4C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NTNG1
• WHRN
• DOLK