Seroatlas · Human Serome Atlas

LRRN3

Leucine-rich repeat neuronal protein 3

Also known as: FIGLER5, FLJ11129, LRRN3_HUMAN, NLRR3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H3W5
Gene
LRRN3
Ensembl
ENSG00000173114
Chromosome
7
Canonical length
708 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

708 residues, UniProt reviewed canonical sequence.

>Q9H3W5|LRRN3
     1  MKDMPLRIHV LLGLAITTLV QAVDKKVDCP RLCTCEIRPW FTPRSIYMEA STVDCNDLGL
    61  LTFPARLPAN TQILLLQTNN IAKIEYSTDF PVNLTGLDLS QNNLSSVTNI NVKKMPQLLS
   121  VYLEENKLTE LPEKCLSELS NLQELYINHN LLSTISPGAF IGLHNLLRLH LNSNRLQMIN
   181  SKWFDALPNL EILMIGENPI IRIKDMNFKP LINLRSLVIA GINLTEIPDN ALVGLENLES
   241  ISFYDNRLIK VPHVALQKVV NLKFLDLNKN PINRIRRGDF SNMLHLKELG INNMPELISI
   301  DSLAVDNLPD LRKIEATNNP RLSYIHPNAF FRLPKLESLM LNSNALSALY HGTIESLPNL
   361  KEISIHSNPI RCDCVIRWMN MNKTNIRFME PDSLFCVDPP EFQGQNVRQV HFRDMMEICL
   421  PLIAPESFPS NLNVEAGSYV SFHCRATAEP QPEIYWITPS GQKLLPNTLT DKFYVHSEGT
   481  LDINGVTPKE GGLYTCIATN LVGADLKSVM IKVDGSFPQD NNGSLNIKIR DIQANSVLVS
   541  WKASSKILKS SVKWTAFVKT ENSHAAQSAR IPSDVKVYNL THLNPSTEYK ICIDIPTIYQ
   601  KNRKKCVNVT TKGLHPDQKE YEKNNTTTLM ACLGGLLGII GVICLISCLS PEMNCDGGHS
   661  YVRNYLQKPT FALGELYPPL INLWEAGKEK STSLKVKATV IGLPTNMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 22 nTPM
  • thyroid gland: 18 nTPM
  • cerebral cortex: 17 nTPM
  • basal ganglia: 16 nTPM
  • testis: 14 nTPM
  • hypothalamus: 9.8 nTPM

Single-cell type

  • epicardial cells: 150 nCPM
  • retinal amacrine cells: 122 nCPM
  • sertoli cells: 121 nCPM
  • adipocytes: 116 nCPM
  • leydig cells: 88 nCPM
  • adrenal medulla cells: 85 nCPM

Immune cell

  • naive CD4 T-cell: 33 nTPM
  • naive CD8 T-cell: 31 nTPM
  • total PBMC: 6.1 nTPM
  • memory CD4 T-cell: 2.7 nTPM
  • memory CD8 T-cell: 2 nTPM
  • memory B-cell: 0.4 nTPM

Brain region

  • cerebral cortex: 31 nTPM
  • hypothalamus: 28 nTPM
  • basal ganglia: 27 nTPM
  • thalamus: 23 nTPM
  • cerebellum: 22 nTPM
  • amygdala: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0.03
gnomAD missense Z
1.04
DepMap mean gene effect
0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRN3 as an antibody target. Whether an autoantibody or antibody against LRRN3 could matter depends on whether native LRRN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRN3 is annotated at the cell surface, where native LRRN3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRN3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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