LRRC3
Leucine-rich repeat-containing protein 3
Also known as: C21orf102, C21orf30, DKFZP434C128, LRRC3_HUMAN, LRRC3DN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BY71
- Gene
- LRRC3
- Ensembl
- ENSG00000160233
- Chromosome
- 21
- Canonical length
- 257 aa
- Protein class
- Plasma proteins, Predicted membrane proteins
OverviewNCBI Gene
Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
257 residues, UniProt reviewed canonical sequence.
>Q9BY71|LRRC3
1 MGTVRPPRPS LLLVSTRESC LFLLFCLHLG AACPQPCRCP DHAGAVAVFC SLRGLQEVPE
61 DIPANTVLLK LDANKISHLP DGAFQHLHRL RELDLSHNAI EAIGSATFAG LAGGLRLLDL
121 SYNRIQRIPK DALGKLSAKI RLSHNPLHCE CALQEALWEL KLDPDSVDEI ACHTSVQEEF
181 VGKPLVQALD AGASLCSVPH RTTDVAMLVT MFGWFAMVIA YVVYYVRHNQ EDARRHLEYL
241 KSLPSAPASK DPIGPGPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LRRC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 15 nTPM
Expression across tissuesHPA
Tissue
- liver: 15 nTPM
- colon: 6.3 nTPM
- stomach: 3.7 nTPM
- blood vessel: 3.3 nTPM
- ovary: 3.2 nTPM
- urinary bladder: 2.1 nTPM
Single-cell type
- hepatocytes: 35 nCPM
- extravillous trophoblasts: 9.6 nCPM
- gastric progenitor cells: 6.4 nCPM
- pituicytes/fscs: 4.3 nCPM
- undifferentiated spermatogonia: 3.9 nCPM
- ovarian stromal cells: 3.7 nCPM
Immune cell
- basophil: 0.3 nTPM
- neutrophil: 0.3 nTPM
- classical monocyte: 0.1 nTPM
- intermediate monocyte: 0.1 nTPM
- MAIT T-cell: 0.1 nTPM
- memory B-cell: 0.1 nTPM
Brain region
- hypothalamus: 4.7 nTPM
- midbrain: 2.4 nTPM
- amygdala: 2 nTPM
- cerebral cortex: 1.9 nTPM
- medulla oblongata: 1.8 nTPM
- pons: 1.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.72
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.26
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LRRC3 as an antibody target. Whether an autoantibody or antibody against LRRC3 could matter depends on whether native LRRC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LRRC3 is annotated at the cell surface, where native LRRC3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label LRRC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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