Seroatlas · Human Serome Atlas

LRRC3C

Leucine-rich repeat-containing protein 3C

Also known as: LRR3C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NJW4
Gene: LRRC3C
Ensembl: ENSG00000204913
Chromosome: 17
Canonical length: 275 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>A6NJW4|LRRC3C
     1  MRMTSSSFVS YCTPGLCQFM AMLPTAGHLL PLLLVIGTGG TVPSPQVPPR GCYVAKEAGE
    61  RTFRCSQAGL SAVPSGIPND TRKLYLDANQ LASVPAGAFQ HLPVLEELDL SHNALAHLSG
   121  AAFQGLEGTL RHLDLSANQL ASVPVEAFVG LQIQVNLSAN PWHCDCALQE VLRQVRLVPG
   181  TGTGIVCGSG ARPDLVGQEF LLLAGEEELC GSGWGGARRS TDVALLVTMG GWLTLMVAYL
   241  VHYVWQNRDE TRRSLKRAPV LPVRSEDSSI LSTVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

epididymis: 1 nTPM
testis: 0.9 nTPM
adipose tissue: 0.4 nTPM
choroid plexus: 0.3 nTPM
heart muscle: 0.2 nTPM
liver: 0.2 nTPM

Single-cell type

early spermatids: 7.4 nCPM
late primary spermatocytes: 5.8 nCPM
epididymal principal cells: 4.8 nCPM
late spermatids: 4 nCPM
hepatocytes: 1.7 nCPM
peritubular myoid cells: 0.7 nCPM

Immune cell

memory B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 0.6 nTPM
white matter: 0.6 nTPM
medulla oblongata: 0.5 nTPM
pons: 0.5 nTPM
basal ganglia: 0.4 nTPM
cerebral cortex: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0.03
gnomAD missense Z: 0.57
DepMap mean gene effect: -0.18
DepMap dependency class: selective

OntologyGO

Molecular functions

signaling receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC3C as an antibody target. Whether an autoantibody or antibody against LRRC3C could matter depends on whether native LRRC3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC3C is annotated at the cell surface, where native LRRC3C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRC3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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