Seroatlas · Human Serome Atlas

ELFN2

Protein phosphatase 1 regulatory subunit 29

Also known as: dJ63G5.3, KIAA1904, LRRC62, PPP1R29, PPR29_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5R3F8
Gene
ELFN2
Ensembl
ENSG00000166897
Chromosome
22
Canonical length
820 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in synaptic membrane adhesion. Predicted to act upstream of or within chemical synaptic transmission; establishment of protein localization; and gene expression. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

820 residues, UniProt reviewed canonical sequence.

>Q5R3F8|ELFN2
     1  MLRLGLCAAA LLCVCRPGAV RADCWLIEGD KGYVWLAICS QNQPPYETIP QHINSTVHDL
    61  RLNENKLKAV LYSSLNRFGN LTDLNLTKNE ISYIEDGAFL GQSSLQVLQL GYNKLSNLTE
   121  GMLRGMSRLQ FLFVQHNLIE VVTPTAFSEC PSLISIDLSS NRLSRLDGAT FASLASLMVC
   181  ELAGNPFNCE CDLFGFLAWL VVFNNVTKNY DRLQCESPRE FAGYPLLVPR PYHSLNAITV
   241  LQAKCRNGSL PARPVSHPTP YSTDAQREPD ENSGFNPDEI LSVEPPASST TDASAGPAIK
   301  LHHVTFTSAT LVVIIPHPYS KMYILVQYNN SYFSDVMTLK NKKEIVTLDK LRAHTEYTFC
   361  VTSLRNSRRF NHTCLTFTTR DPVPGDLAPS TSTTTHYIMT ILGCLFGMVI VLGAVYYCLR
   421  KRRMQEEKQK SVNVKKTILE MRYGADVDAG SIVHAAQKLG EPPVLPVSRM ASIPSMIGEK
   481  LPTAKGLEAG LDTPKVATKG NYIEVRTGAG GDGLARPEDD LPDLENGQGS AAEISTIAKE
   541  VDKVNQIINN CIDALKLDSA SFLGGGSSSG DPELAFECQS LPAAAAASSA TGPGALERPS
   601  FLSPPYKESS HHPLQRQLSA DAAVTRKTCS VSSSGSIKSA KVFSLDVPDH PAATGLAKGD
   661  SKYIEKGSPL NSPLDRLPLV PAGSGGGSGG GGGIHHLEVK PAYHCSEHRH SFPALYYEEG
   721  ADSLSQRVSF LKPLTRSKRD STYSQLSPRH YYSGYSSSPE YSSESTHKIW ERFRPYKKHH
   781  REEVYMAAGH ALRKKVQFAK DEDLHDILDY WKGVSAQQKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELFN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 17 nTPM
  • amygdala: 16 nTPM
  • hippocampal formation: 14 nTPM
  • basal ganglia: 11 nTPM
  • hypothalamus: 9 nTPM
  • midbrain: 6.3 nTPM

Single-cell type

  • proximal tubule cells: 16 nCPM
  • loop of henle epithelial cells: 5.2 nCPM
  • renal connecting tubule cells: 2.5 nCPM
  • distal convoluted tubule cells: 1.4 nCPM
  • oligodendrocyte progenitor cells: 1 nCPM
  • renal collecting duct principal cells: 0.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 65 nTPM
  • cerebral cortex: 63 nTPM
  • hippocampal formation: 58 nTPM
  • basal ganglia: 55 nTPM
  • white matter: 36 nTPM
  • thalamus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
gnomAD missense Z
2.16
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELFN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELFN2 as an antibody target. Whether an autoantibody or antibody against ELFN2 could matter depends on whether native ELFN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELFN2 is annotated at the cell surface, where native ELFN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ELFN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ELFN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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