Seroatlas · Human Serome Atlas

LRTM1

Leucine-rich repeat and transmembrane domain-containing protein 1

Also known as: HT017, LRTM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBL6
Gene: LRTM1
Ensembl: ENSG00000144771
Chromosome: 3
Canonical length: 345 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>Q9HBL6|LRTM1
     1  MKGELLLFSS VIVLLQVVCS CPDKCYCQSS TNFVDCSQQG LAEIPSHLPP QTRTLHLQDN
    61  QIHHLPAFAF RSVPWLMTLN LSNNSLSNLA PGAFHGLQHL QVLNLTQNSL LSLESRLFHS
   121  LPQLRELDLS SNNISHLPTS LGETWENLTI LAVQQNQLQQ LDRALLESMP SVRLLLLKDN
   181  LWKCNCHLLG LKLWLEKFVY KGGLTDGIIC ESPDTWKGKD LLRIPHELYQ PCPLPAPDPV
   241  SSQAQWPGSA HGVVLRPPEN HNAGERELLE CELKPKPRPA NLRHAIATVI ITGVVCGIVC
   301  LMMLAAAIYG CTYAAITAQY HGGPLAQTND PGKVEEKERF DSSPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRTM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

retina: 73 nTPM
skeletal muscle: 24 nTPM
choroid plexus: 14 nTPM
spleen: 6.4 nTPM
esophagus: 3.7 nTPM
tongue: 2.3 nTPM

Single-cell type

retinal bipolar cells: 327 nCPM
epicardial cells: 216 nCPM
retinal ganglion cells: 85 nCPM
myonuclei: 61 nCPM
brain inhibitory neurons: 43 nCPM
cardiomyocytes: 42 nCPM

Immune cell

basophil: 0.5 nTPM
non-classical monocyte: 0.3 nTPM
neutrophil: 0.2 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

basal ganglia: 9.5 nTPM
hypothalamus: 9.5 nTPM
cerebral cortex: 9.3 nTPM
white matter: 8.5 nTPM
choroid plexus: 8.1 nTPM
hippocampal formation: 6.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: -0.84
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRTM1 as an antibody target. Whether an autoantibody or antibody against LRTM1 could matter depends on whether native LRTM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRTM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRTM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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