Seroatlas · Human Serome Atlas

RTN4R

Reticulon-4 receptor

Also known as: NOGOR, RTN4R_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BZR6
Gene
RTN4R
Ensembl
ENSG00000040608
Chromosome
22
Canonical length
473 aa
Protein class
Disease related genes, Human disease related genes, Predicted membrane proteins
Subcellular location
Plasma membrane,Actin filaments,Focal adhesion sites
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

473 residues, UniProt reviewed canonical sequence.

>Q9BZR6|RTN4R
     1  MKRASAGGSR LLAWVLWLQA WQVAAPCPGA CVCYNEPKVT TSCPQQGLQA VPVGIPAASQ
    61  RIFLHGNRIS HVPAASFRAC RNLTILWLHS NVLARIDAAA FTGLALLEQL DLSDNAQLRS
   121  VDPATFHGLG RLHTLHLDRC GLQELGPGLF RGLAALQYLY LQDNALQALP DDTFRDLGNL
   181  THLFLHGNRI SSVPERAFRG LHSLDRLLLH QNRVAHVHPH AFRDLGRLMT LYLFANNLSA
   241  LPTEALAPLR ALQYLRLNDN PWVCDCRARP LWAWLQKFRG SSSEVPCSLP QRLAGRDLKR
   301  LAANDLQGCA VATGPYHPIW TGRATDEEPL GLPKCCQPDA ADKASVLEPG RPASAGNALK
   361  GRVPPGDSPP GNGSGPRHIN DSPFGTLPGS AEPPLTAVRP EGSEPPGFPT SGPRRRPGCS
   421  RKNRTRSHCR LGQAGSGGGG TGDSEGSGAL PSLTCSLTPL GLALVLWTVL GPC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTN4R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
83 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 83 nTPM
  • cerebral cortex: 54 nTPM
  • amygdala: 28 nTPM
  • hippocampal formation: 24 nTPM
  • liver: 13 nTPM
  • spinal cord: 8.5 nTPM

Single-cell type

  • brain excitatory neurons: 26 nCPM
  • extravillous trophoblasts: 13 nCPM
  • respiratory deuterosomal cells: 11 nCPM
  • müller glia: 11 nCPM
  • retinal bipolar cells: 10 nCPM
  • bergmann glia: 9.9 nCPM

Immune cell

  • MAIT T-cell: 11 nTPM
  • naive CD8 T-cell: 5.1 nTPM
  • gdT-cell: 4.6 nTPM
  • memory CD8 T-cell: 4.6 nTPM
  • memory CD4 T-cell: 4.1 nTPM
  • T-reg: 3 nTPM

Brain region

  • cerebellum: 77 nTPM
  • cerebral cortex: 76 nTPM
  • hippocampal formation: 55 nTPM
  • basal ganglia: 53 nTPM
  • amygdala: 50 nTPM
  • white matter: 36 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RTN4R.

Disease | AllUniProt

Conditions RTN4R is implicated in, by any mechanism.

Disease | ImmuneIEDB

Conditions an epitope on RTN4R was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.96
gnomAD missense Z
1.13
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RTN4R in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTN4R as an antibody target. Whether an autoantibody or antibody against RTN4R could matter depends on whether native RTN4R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTN4R is annotated at the cell surface, where native RTN4R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RTN4R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RTN4R. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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