CETN1
Centrin-1
Also known as: CEN1, CETN, CETN1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q12798
- Gene
- CETN1
- Ensembl
- ENSG00000177143
- Chromosome
- 18
- Canonical length
- 172 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Flagellar centriole,Mid piece,Principal piece
OverviewNCBI Gene
The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. [provided by RefSeq, Jan 2015]
Canonical amino-acid sequenceUniProt
172 residues, UniProt reviewed canonical sequence.
>Q12798|CETN1
1 MASGFKKPSA ASTGQKRKVA PKPELTEDQK QEVREAFDLF DVDGSGTIDA KELKVAMRAL
61 GFEPRKEEMK KMISEVDREG TGKISFNDFL AVMTQKMSEK DTKEEILKAF RLFDDDETGK
121 ISFKNLKRVA NELGENLTDE ELQEMIDEAD RDGDGEVNEE EFLRIMKKTS LYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CETN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 128 nTPM
Expression across tissuesHPA
Tissue
- testis: 128 nTPM
- prostate: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- late primary spermatocytes: 2,026 nCPM
- early spermatids: 771 nCPM
- late spermatids: 495 nCPM
- early primary spermatocytes: 93 nCPM
- sertoli cells: 14 nCPM
- differentiating spermatogonia: 7.3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.48
- gnomAD pLI
- 0.22
- gnomAD missense Z
- 0.82
- DepMap mean gene effect
- 0.12
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- calcium ion binding
- G-protein beta/gamma-subunit complex binding
- heterotrimeric G-protein binding
- microtubule binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CETN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CETN1 as an antibody target. Whether an autoantibody or antibody against CETN1 could matter depends on whether native CETN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CETN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CETN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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