Seroatlas · Human Serome Atlas

CETN2

Centrin-2

Also known as: CALT, CEN2, CETN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P41208
Gene: CETN2
Ensembl: ENSG00000147400
Chromosome: X
Canonical length: 172 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Flagellar centriole,Mid piece,Principal piece
Quaternary structure: Homooligomer

OverviewNCBI Gene

Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>P41208|CETN2
     1  MASNFKKANM ASSSQRKRMS PKPELTEEQK QEIREAFDLF DADGTGTIDV KELKVAMRAL
    61  GFEPKKEEIK KMISEIDKEG TGKMNFGDFL TVMTQKMSEK DTKEEILKAF KLFDDDETGK
   121  ISFKNLKRVA KELGENLTDE ELQEMIDEAD RDGDGEVSEQ EFLRIMKKTS LY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CETN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 234 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 234 nTPM
fallopian tube: 229 nTPM
epididymis: 110 nTPM
hypothalamus: 88 nTPM
kidney: 73 nTPM
seminal vesicle: 73 nTPM

Single-cell type

fallopian tube ciliated cells: 1,357 nCPM
respiratory ciliated cells: 1,032 nCPM
epididymal efferent duct ciliated cells: 1,014 nCPM
endometrial ciliated cells: 661 nCPM
epididymal principal cells: 233 nCPM
esophageal apical cells: 174 nCPM

Immune cell

eosinophil: 36 nTPM
plasmacytoid DC: 20 nTPM
basophil: 20 nTPM
MAIT T-cell: 14 nTPM
non-classical monocyte: 14 nTPM
intermediate monocyte: 14 nTPM

Brain region

choroid plexus: 92 nTPM
midbrain: 61 nTPM
medulla oblongata: 50 nTPM
spinal cord: 43 nTPM
white matter: 41 nTPM
hypothalamus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.5
gnomAD missense Z: 1.5
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CETN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CETN2 as an antibody target. Whether an autoantibody or antibody against CETN2 could matter depends on whether native CETN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CETN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CETN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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