Sushi/SCR/CCP domain
IPR000436
Definition
The extracellular sushi domain is characterised by a consensus sequence spanning ~60 residues containing four invariant cysteine residues forming two disulfide-bridges (I-III and II-IV), a highly conserved tryptophan, and conserved glycine, proline, and hydrophobic residues PMID:2751824. Sushi domains are known to be involved in many recognition processes, including the binding of several complement factors to fragments C3b and C4b PMID:2751824. The sushi domain is also known as the complement control protein (CCP) module or the short consensus repeat (SCR).
55 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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