Seroatlas · Human Serome Atlas

SRPX2

Sushi repeat-containing protein SRPX2

Also known as: SRPUL, SRPX2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60687
Gene
SRPX2
Ensembl
ENSG00000102359
Chromosome
X
Canonical length
465 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood
Quaternary structure
Homooligomer

OverviewNCBI Gene

This gene encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and cognitive disability. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>O60687|SRPX2
     1  MASQLTQRGA LFLLFFLTPA VTPTWYAGSG YYPDESYNEV YAEEVPQAPA LDYRVPRWCY
    61  TLNIQDGEAT CYSPKGGNYH SSLGTRCELS CDRGFRLIGR RSVQCLPSRR WSGTAYCRQM
   121  RCHALPFITS GTYTCTNGVL LDSRCDYSCS SGYHLEGDRS RICMEDGRWS GGEPVCVDID
   181  PPKIRCPHSR EKMAEPEKLT ARVYWDPPLV KDSADGTITR VTLRGPEPGS HFPEGEHVIR
   241  YTAYDRAYNR ASCKFIVKVQ VRRCPTLKPP QHGYLTCTSA GDNYGATCEY HCDGGYDRQG
   301  TPSRVCQSSR QWSGSPPICA PMKINVNVNS AAGLLDQFYE KQRLLIISAP DPSNRYYKMQ
   361  ISMLQQSTCG LDLRHVTIIE LVGQPPQEVG RIREQQLSAN IIEELRQFQR LTRSYFNMVL
   421  IDKQGIDRDR YMEPVTPEEI FTFIDDYLLS NQELTQRREQ RDICE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRPX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 30 nTPM
  • breast: 20 nTPM
  • esophagus: 17 nTPM
  • urinary bladder: 16 nTPM
  • kidney: 13 nTPM
  • lung: 13 nTPM

Single-cell type

  • esophageal apical cells: 479 nCPM
  • adipocytes: 273 nCPM
  • urothelial cells: 252 nCPM
  • fibro-adipogenic progenitors: 190 nCPM
  • prostatic hillock cells: 165 nCPM
  • fibroblasts: 158 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 18 nTPM
  • hypothalamus: 16 nTPM
  • midbrain: 13 nTPM
  • thalamus: 11 nTPM
  • medulla oblongata: 10 nTPM
  • basal ganglia: 9.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SRPX2.

Disease | AllUniProt

Conditions SRPX2 is implicated in, by any mechanism.

  • Rolandic epilepsy, impaired intellectual development, and speech dyspraxia, X-linked (RESDX) MIM:300643

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 241 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Rolandic epilepsy, intellectual disability, and speech dyspraxia, X-linked

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.05
gnomAD missense Z
0.23
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRPX2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRPX2 as an antibody target. Whether an autoantibody or antibody against SRPX2 could matter depends on whether native SRPX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRPX2 is annotated at the cell surface, where native SRPX2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SRPX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRPX2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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