Seroatlas · Human Serome Atlas

CFHR1

Complement factor H-related protein 1

Also known as: CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, FHR1_HUMAN, H36-1, H36-2, HFL1, HFL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q03591
Gene
CFHR1
Ensembl
ENSG00000244414
Chromosome
1
Canonical length
330 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>Q03591|CFHR1
     1  MWLLVSVILI SRISSVGGEA TFCDFPKINH GILYDEEKYK PFSQVPTGEV FYYSCEYNFV
    61  SPSKSFWTRI TCTEEGWSPT PKCLRLCFFP FVENGHSESS GQTHLEGDTV QIICNTGYRL
   121  QNNENNISCV ERGWSTPPKC RSTDTSCVNP PTVQNAHILS RQMSKYPSGE RVRYECRSPY
   181  EMFGDEEVMC LNGNWTEPPQ CKDSTGKCGP PPPIDNGDIT SFPLSVYAPA SSVEYQCQNL
   241  YQLEGNKRIT CRNGQWSEPP KCLHPCVISR EIMENYNIAL RWTAKQKLYL RTGESAEFVC
   301  KRGYRLSSRS HTLRTTCWDG KLEYPTCAKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFHR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
1,937 nTPM

Expression across tissuesHPA

Tissue

  • liver: 1,937 nTPM
  • lymph node: 8.6 nTPM
  • kidney: 7.4 nTPM
  • spleen: 5.5 nTPM
  • ovary: 2.6 nTPM
  • appendix: 2.2 nTPM

Single-cell type

  • hepatocytes: 131 nCPM
  • granulosa cells: 50 nCPM
  • kupffer cells: 15 nCPM
  • hofbauer cells: 13 nCPM
  • ovarian stromal cells: 7.3 nCPM
  • pericytes: 5.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 1.7 nTPM
  • pons: 0.8 nTPM
  • thalamus: 0.4 nTPM
  • hypothalamus: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM
  • cerebral cortex: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CFHR1.

Disease | AllUniProt

Conditions CFHR1 is implicated in, by any mechanism.

  • Hemolytic uremic syndrome, atypical, 1 (AHUS1) MIM:235400

Disease | ImmuneIEDB

Conditions an epitope on CFHR1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.53
gnomAD pLI
0
gnomAD missense Z
-0.33
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFHR1 as an antibody target. Whether an autoantibody or antibody against CFHR1 could matter depends on whether native CFHR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFHR1 is annotated as secreted, so native CFHR1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CFHR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CFHR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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