Seroatlas · Human Serome Atlas

IL15RA

Interleukin-15 receptor subunit alpha

Also known as: CD215, I15RA_HUMAN, IL-15RA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13261
Gene
IL15RA
Ensembl
ENSG00000134470
Chromosome
10
Canonical length
267 aa
Protein class
CD markers, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Vesicles,Plasma membrane,Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

267 residues, UniProt reviewed canonical sequence.

>Q13261|IL15RA
     1  MAPRRARGCR TLGLPALLLL LLLRPPATRG ITCPPPMSVE HADIWVKSYS LYSRERYICN
    61  SGFKRKAGTS SLTECVLNKA TNVAHWTTPS LKCIRDPALV HQRPAPPSTV TTAGVTPQPE
   121  SLSPSGKEPA ASSPSSNNTA ATTAAIVPGS QLMPSKSPST GTTEISSHES SHGTPSQTTA
   181  KNWELTASAS HQPPGVYPQG HSDTTVAIST STVLLCGLSA VSLLACYLKS RQTPPLASVE
   241  MEAMEALPVT WGTSSRDEDL ENCSHHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL15RA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • lung: 46 nTPM
  • urinary bladder: 24 nTPM
  • gallbladder: 22 nTPM
  • liver: 21 nTPM
  • lymph node: 20 nTPM
  • adipose tissue: 20 nTPM

Single-cell type

  • decidual stromal cells: 92 nCPM
  • fibroblasts: 70 nCPM
  • pancreatic acinar cells: 68 nCPM
  • cholangiocytes: 63 nCPM
  • vascular endothelial cells: 58 nCPM
  • sertoli cells: 55 nCPM

Immune cell

  • intermediate monocyte: 33 nTPM
  • MAIT T-cell: 29 nTPM
  • classical monocyte: 26 nTPM
  • non-classical monocyte: 21 nTPM
  • memory CD8 T-cell: 20 nTPM
  • gdT-cell: 19 nTPM

Brain region

  • medulla oblongata: 11 nTPM
  • spinal cord: 9.1 nTPM
  • thalamus: 9 nTPM
  • pons: 8.8 nTPM
  • hypothalamus: 8 nTPM
  • cerebral cortex: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.58
gnomAD pLI
0
gnomAD missense Z
0.23
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL15RA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL15RA as an antibody target. Whether an autoantibody or antibody against IL15RA could matter depends on whether native IL15RA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL15RA is annotated at the cell surface, where native IL15RA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL15RA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL15RA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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