Seroatlas · Human Serome Atlas

SUSD3

Sushi domain-containing protein 3

Also known as: MGC26847, SUSD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96L08
Gene
SUSD3
Ensembl
ENSG00000157303
Chromosome
9
Canonical length
255 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>Q96L08|SUSD3
     1  MRWAAATLRG KARPRGRAGV TTPAPGNRTG TCAKLRLPPQ ATFQVLRGNG ASVGTVLMFR
    61  CPSNHQMVGS GLLTCTWKGS IAEWSSGSPV CKLVPPHETF GFKVAVIASI VSCAIILLMS
   121  MAFLTCCLLK CVKKSKRRRS NRSAQLWSQL KDEDLETVQA AYLGLKHFNK PVSGPSQAHD
   181  NHSFTTDHGE STSKLASVTR SVDKDPGIPR ALSLSGSSSS PQAQVMVHMA NPRQPLPASG
   241  LATGMPQQPA AYALG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUSD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • testis: 76 nTPM
  • lymph node: 54 nTPM
  • ovary: 40 nTPM
  • bone marrow: 39 nTPM
  • spleen: 35 nTPM
  • fallopian tube: 33 nTPM

Single-cell type

  • granulosa cells: 240 nCPM
  • platelets: 123 nCPM
  • megakaryocytes: 118 nCPM
  • hofbauer cells: 107 nCPM
  • microglia: 101 nCPM
  • sertoli cells: 101 nCPM

Immune cell

  • naive CD4 T-cell: 216 nTPM
  • T-reg: 184 nTPM
  • memory CD4 T-cell: 125 nTPM
  • memory B-cell: 89 nTPM
  • naive CD8 T-cell: 88 nTPM
  • eosinophil: 79 nTPM

Brain region

  • white matter: 14 nTPM
  • medulla oblongata: 11 nTPM
  • spinal cord: 11 nTPM
  • pons: 10 nTPM
  • thalamus: 9.5 nTPM
  • hypothalamus: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.31
gnomAD pLI
0
gnomAD missense Z
1.07
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUSD3 as an antibody target. Whether an autoantibody or antibody against SUSD3 could matter depends on whether native SUSD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUSD3 is annotated at the cell surface, where native SUSD3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SUSD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SUSD3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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