Seroatlas · Human Serome Atlas

SUSD4

Sushi domain-containing protein 4

Also known as: FLJ10052, SUSD4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VX71
Gene: SUSD4
Ensembl: ENSG00000143502
Chromosome: 1
Canonical length: 490 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Involved in negative regulation of complement activation, alternative pathway and negative regulation of complement activation, classical pathway. Predicted to be located in extracellular region and membrane. Predicted to be active in parallel fiber to Purkinje cell synapse and postsynaptic membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

490 residues, UniProt reviewed canonical sequence.

>Q5VX71|SUSD4
     1  MYHGMNPSNG DGFLEQQQQQ QQPQSPQRLL AVILWFQLAL CFGPAQLTGG FDDLQVCADP
    61  GIPENGFRTP SGGVFFEGSV ARFHCQDGFK LKGATKRLCL KHFNGTLGWI PSDNSICVQE
   121  DCRIPQIEDA EIHNKTYRHG EKLIITCHEG FKIRYPDLHN MVSLCRDDGT WNNLPICQGC
   181  LRPLASSNGY VNISELQTSF PVGTVISYRC FPGFKLDGSA YLECLQNLIW SSSPPRCLAL
   241  EVCPLPPMVS HGDFVCHPRP CERYNHGTVV EFYCDPGYSL TSDYKYITCQ YGEWFPSYQV
   301  YCIKSEQTWP STHETLLTTW KIVAFTATSV LLVLLLVILA RMFQTKFKAH FPPRGPPRSS
   361  SSDPDFVVVD GVPVMLPSYD EAVSGGLSAL GPGYMASVGQ GCPLPVDDQS PPAYPGSGDT
   421  DTGPGESETC DSVSGSSELL QSLYSPPRCQ ESTHPASDNP DIIASTAEEV ASTSPGIDIA
   481  DEIPLMEEDP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUSD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 48 nTPM
esophagus: 47 nTPM
basal ganglia: 43 nTPM
ovary: 40 nTPM
hypothalamus: 29 nTPM
cerebral cortex: 29 nTPM

Single-cell type

somatotrophs: 282 nCPM
esophageal suprabasal cells: 272 nCPM
retinal amacrine cells: 241 nCPM
esophageal apical cells: 230 nCPM
brain excitatory neurons: 179 nCPM
brain inhibitory neurons: 178 nCPM

Immune cell

naive CD4 T-cell: 10 nTPM
memory CD4 T-cell: 6.8 nTPM
MAIT T-cell: 5.5 nTPM
naive CD8 T-cell: 1.9 nTPM
memory CD8 T-cell: 1.7 nTPM
total PBMC: 1.4 nTPM

Brain region

hippocampal formation: 165 nTPM
cerebral cortex: 154 nTPM
amygdala: 78 nTPM
hypothalamus: 77 nTPM
basal ganglia: 64 nTPM
pons: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 0.7
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUSD4 as an antibody target. Whether an autoantibody or antibody against SUSD4 could matter depends on whether native SUSD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUSD4 is annotated as secreted, so native SUSD4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SUSD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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