Seroatlas · Human Serome Atlas

C1R

Complement C1r subcomponent

Also known as: C1R_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P00736
Gene
C1R
Canonical length
705 aa
Protein class
Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C1R in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

705 residues, UniProt reviewed canonical sequence.

>P00736|C1R
     1  MWLLYLLVPA LFCRAGGSIP IPQKLFGEVT SPLFPKPYPN NFETTTVITV PTGYRVKLVF
    61  QQFDLEPSEG CFYDYVKISA DKKSLGRFCG QLGSPLGNPP GKKEFMSQGN KMLLTFHTDF
   121  SNEENGTIMF YKGFLAYYQA VDLDECASRS KSGEEDPQPQ CQHLCHNYVG GYFCSCRPGY
   181  ELQEDTHSCQ AECSSELYTE ASGYISSLEY PRSYPPDLRC NYSIRVERGL TLHLKFLEPF
   241  DIDDHQQVHC PYDQLQIYAN GKNIGEFCGK QRPPDLDTSS NAVDLLFFTD ESGDSRGWKL
   301  RYTTEIIKCP QPKTLDEFTI IQNLQPQYQF RDYFIATCKQ GYQLIEGNQV LHSFTAVCQD
   361  DGTWHRAMPR CKIKDCGQPR NLPNGDFRYT TTMGVNTYKA RIQYYCHEPY YKMQTRAGSR
   421  ESEQGVYTCT AQGIWKNEQK GEKIPRCLPV CGKPVNPVEQ RQRIIGGQKA KMGNFPWQVF
   481  TNIHGRGGGA LLGDRWILTA AHTLYPKEHE AQSNASLDVF LGHTNVEELM KLGNHPIRRV
   541  SVHPDYRQDE SYNFEGDIAL LELENSVTLG PNLLPICLPD NDTFYDLGLM GYVSGFGVME
   601  EKIAHDLRFV RLPVANPQAC ENWLRGKNRM DVFSQNMFCA GHPSLKQDAC QGDSGGVFAV
   661  RDPNTDRWVA TGIVSWGIGC SRGYGFYTKV LNYVDWIKKE MEEED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
1,733 nTPM

Expression across tissuesHPA

Tissue

  • liver: 1,733 nTPM
  • ovary: 697 nTPM
  • blood vessel: 659 nTPM
  • adipose tissue: 589 nTPM
  • urinary bladder: 551 nTPM
  • heart muscle: 510 nTPM

Single-cell type

  • epicardial cells: 46 nCPM
  • fibroblasts: 38 nCPM
  • podocytes: 35 nCPM
  • mesothelial cells: 23 nCPM
  • endometrial stromal cells: 14 nCPM
  • pericytes: 13 nCPM

Immune cell

  • NK-cell: 0.8 nTPM
  • memory CD8 T-cell: 0.7 nTPM
  • eosinophil: 0.6 nTPM
  • naive CD4 T-cell: 0.6 nTPM
  • naive CD8 T-cell: 0.6 nTPM
  • MAIT T-cell: 0.5 nTPM

Brain region

  • medulla oblongata: 23 nTPM
  • choroid plexus: 20 nTPM
  • midbrain: 17 nTPM
  • hypothalamus: 17 nTPM
  • spinal cord: 13 nTPM
  • thalamus: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about C1R.

Disease | AllUniProt

Conditions C1R is implicated in, by any mechanism.

  • Ehlers-Danlos syndrome, periodontal type, 1 (EDSPD1) MIM:130080

Disease | GeneticClinVar

19 pathogenic / likely-pathogenic of 159 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on C1R was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.78
gnomAD missense Z
2.03

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1R as an antibody target. Whether an autoantibody or antibody against C1R could matter depends on whether native C1R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1R is annotated at the cell surface, where native C1R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label C1R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1R. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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