Seroatlas · Human Serome Atlas

SUSD6

Sushi domain-containing protein 6

Also known as: KIAA0247, SUSD6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92537
Gene: SUSD6
Ensembl: ENSG00000100647
Chromosome: 14
Canonical length: 303 aa
Protein class: Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Involved in DNA damage response. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>Q92537|SUSD6
     1  MCHGRIAPKS TSVFAVASVG HGVFLPLVIL CTLLGDGLAS VCPLPPEPEN GGYICHPRPC
    61  RDPLTAGSVI EYLCAEGYML KGDYKYLTCK NGEWKPAMEI SCRLNEDKDT HTSLGVPTLS
   121  IVASTASSVA LILLLVVLFV LLQPKLKSFH HSRRDQGVSG DQVSIMVDGV QVALPSYEEA
   181  VYGSSGHCVP PADPRVQIVL SEGSGPSGRS VPREQQLPDQ GACSSAGGED EAPGQSGLCE
   241  AWGSRASETV MVHQATTSSW VAGSGNRQLA HKETADSENS DIQSLLSLTS EEYTDDIPLL
   301  KEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUSD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 64 nTPM
epididymis: 41 nTPM
cerebellum: 37 nTPM
lung: 35 nTPM
tonsil: 34 nTPM
spleen: 32 nTPM

Single-cell type

neutrophils: 1,672 nCPM
microglia: 417 nCPM
esophageal apical cells: 361 nCPM
monocytes: 359 nCPM
kupffer cells: 299 nCPM
neutrophil progenitors: 271 nCPM

Immune cell

neutrophil: 33 nTPM
basophil: 16 nTPM
non-classical monocyte: 14 nTPM
eosinophil: 12 nTPM
classical monocyte: 12 nTPM
intermediate monocyte: 10 nTPM

Brain region

cerebellum: 53 nTPM
medulla oblongata: 50 nTPM
spinal cord: 36 nTPM
white matter: 30 nTPM
pons: 30 nTPM
thalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.63
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

DNA damage response

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUSD6 as an antibody target. Whether an autoantibody or antibody against SUSD6 could matter depends on whether native SUSD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUSD6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUSD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...