Seroatlas · Human Serome Atlas

CFHR2

Complement factor H-related protein 2

Also known as: CFHL2, FHR2, FHR2_HUMAN, HFL3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P36980
Gene
CFHR2
Ensembl
ENSG00000080910
Chromosome
1
Canonical length
270 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene belongs to a family of complement factor H-related genes (CFHR), which are clustered together with complement factor H gene on chromosome 1, and are involved in regulation of complement. Mutations in CFHR genes have been associated with dense deposit disease and atypical haemolytic-uraemic syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>P36980|CFHR2
     1  MWLLVSVILI SRISSVGGEA MFCDFPKINH GILYDEEKYK PFSQVPTGEV FYYSCEYNFV
    61  SPSKSFWTRI TCAEEGWSPT PKCLRLCFFP FVENGHSESS GQTHLEGDTV QIICNTGYRL
   121  QNNENNISCV ERGWSTPPKC RSTISAEKCG PPPPIDNGDI TSFLLSVYAP GSSVEYQCQN
   181  LYQLEGNNQI TCRNGQWSEP PKCLDPCVIS QEIMEKYNIK LKWTNQQKLY SRTGDIVEFV
   241  CKSGYHPTKS HSFRAMCQNG KLVYPSCEEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFHR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
1,262 nTPM

Expression across tissuesHPA

Tissue

  • liver: 1,262 nTPM
  • kidney: 0.4 nTPM
  • spleen: 0.3 nTPM
  • adipose tissue: 0.1 nTPM
  • appendix: 0.1 nTPM
  • skeletal muscle: 0.1 nTPM

Single-cell type

  • hepatocytes: 1,476 nCPM
  • kupffer cells: 10 nCPM
  • hepatic stellate cells: 6.5 nCPM
  • cholangiocytes: 3.9 nCPM
  • hofbauer cells: 1.1 nCPM
  • monocytes: 1 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.7 nTPM
  • white matter: 0.7 nTPM
  • cerebellum: 0.6 nTPM
  • choroid plexus: 0.6 nTPM
  • hippocampal formation: 0.6 nTPM
  • basal ganglia: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CFHR2.

Disease | ImmuneIEDB

Conditions an epitope on CFHR2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.82
gnomAD pLI
0
gnomAD missense Z
-0.9
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFHR2 as an antibody target. Whether an autoantibody or antibody against CFHR2 could matter depends on whether native CFHR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFHR2 is annotated as secreted, so native CFHR2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CFHR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CFHR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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