Seroatlas · Human Serome Atlas

SRPX

Sushi repeat-containing protein SRPX

Also known as: ETX1, SRPX_HUMAN, SRPX1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P78539
Gene: SRPX
Ensembl: ENSG00000101955
Chromosome: X
Canonical length: 464 aa
Protein class: Plasma proteins, Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to be an extracellular matrix structural constituent. Predicted to be involved in phagolysosome assembly. Predicted to act upstream of or within several processes, including negative regulation of cell proliferation involved in contact inhibition; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; and response to endoplasmic reticulum stress. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>P78539|SRPX
     1  MGSPAHRPAL LLLLPPLLLL LLLRVPPSRS FPGSGDSPLE DDEVGYSHPR YKDTPWCSPI
    61  KVKYGDVYCR APQGGYYKTA LGTRCDIRCQ KGYELHGSSL LICQSNKRWS DKVICKQKRC
   121  PTLAMPANGG FKCVDGAYFN SRCEYYCSPG YTLKGERTVT CMDNKAWSGR PASCVDMEPP
   181  RIKCPSVKER IAEPNKLTVR VSWETPEGRD TADGILTDVI LKGLPPGSNF PEGDHKIQYT
   241  VYDRAENKGT CKFRVKVRVK RCGKLNAPEN GYMKCSSDGD NYGATCEFSC IGGYELQGSP
   301  ARVCQSNLAW SGTEPTCAAM NVNVGVRTAA ALLDQFYEKR RLLIVSTPTA RNLLYRLQLG
   361  MLQQAQCGLD LRHITVVELV GVFPTLIGRI GAKIMPPALA LQLRLLLRIP LYSFSMVLVD
   421  KHGMDKERYV SLVMPVALFN LIDTFPLRKE EMVLQAEMSQ TCNT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRPX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 206 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 206 nTPM
breast: 145 nTPM
urinary bladder: 103 nTPM
fallopian tube: 93 nTPM
heart muscle: 91 nTPM
blood vessel: 90 nTPM

Single-cell type

decidual stromal cells: 394 nCPM
fibroblasts: 273 nCPM
hepatic stellate cells: 194 nCPM
bergmann glia: 183 nCPM
peritubular myoid cells: 116 nCPM
epididymal basal cells: 100 nCPM

Immune cell

plasmacytoid DC: 7.8 nTPM
neutrophil: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 33 nTPM
hypothalamus: 32 nTPM
medulla oblongata: 29 nTPM
spinal cord: 29 nTPM
white matter: 28 nTPM
midbrain: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SRPX.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 104 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Short stature

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: -0.62
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRPX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PELO

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRPX as an antibody target. Whether an autoantibody or antibody against SRPX could matter depends on whether native SRPX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRPX is annotated at the cell surface, where native SRPX is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SRPX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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