YY2

Protein identityUniProt · HPA

UniProt accession

O15391

Gene

YY2

Ensembl

ENSG00000230797

Chromosome

X

Canonical length

372 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>O15391|YY2
     1  MASNEDFSIT QDLEIPADIV ELHDINVEPL PMEDIPTESV QYEDVDGNWI YGGHNHPPLM
    61  VLQPLFTNTG YGDHDQEMLM LQTQEEVVGY CDSDNQLGND LEDQLALPDS IEDEHFQMTL
   121  ASLSASAAST STSTQSRSKK PSKKPSGKSA TSTEANPAGS SSSLGTRKWE QKQMQVKTLE
   181  GEFSVTMWSP NDNNDQGAVG EGQAENPPDY SEYLKGKKLP PGGLPGIDLS DPKQLAEFTK
   241  VKPKRSKGEP PKTVPCSYSG CEKMFRDYAA MRKHLHIHGP RVHVCAECGK AFLESSKLRR
   301  HQLVHTGEKP FQCTFEGCGK RFSLDFNLRT HLRIHTGDKP FVCPFDVCNR KFAQSTNLKT
   361  HILTHVKTKN NP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YY2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

5.4 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.93

gnomAD pLI

0.41

gnomAD missense Z

1.35

DepMap mean gene effect

0.15

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II

Molecular functions

• cis-regulatory region sequence-specific DNA binding
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
• zinc ion binding

Cellular components

• chromatin
• nucleus
• PcG protein complex
• transcription regulator complex

Protein domainsUniProt · Pfam · InterPro

• Zinc finger C2H2-type
• C2H2-type Zinc finger protein, YY1-like
• Zinc finger C2H2 superfamily
• Zinc finger, C2H2 type

KeywordsUniProt

• Activator
• DNA-binding
• Metal-binding
• Nucleus
• Repeat
• Repressor
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of YY2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• YY1