SFMBT2

Protein identityUniProt · HPA

UniProt accession

Q5VUG0

Gene

SFMBT2

Ensembl

ENSG00000198879

Chromosome

10

Canonical length

894 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

Enables histone binding activity. Involved in negative regulation of gene expression. Located in aggresome; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

894 residues, UniProt reviewed canonical sequence.

>Q5VUG0|SFMBT2
     1  MESTLSASNM QDPSSSPLEK CLGSANGNGD LDSEEGSSLE ETGFNWGEYL EETGASAAPH
    61  TSFKHVEISI QSNFQPGMKL EVANKNNPDT YWVATIITTC GQLLLLRYCG YGEDRRADFW
   121  CDVVIADLHP VGWCTQNNKV LMPPDAIKEK YTDWTEFLIR DLTGSRTAPA NLLEGPLRGK
   181  GPIDLITVGS LIELQDSQNP FQYWIVSVIE NVGGRLRLRY VGLEDTESYD QWLFYLDYRL
   241  RPVGWCQENK YRMDPPSEIY PLKMASEWKC TLEKSLIDAA KFPLPMEVFK DHADLRSHFF
   301  TVGMKLETVN MCEPFYISPA SVTKVFNNHF FQVTIDDLRP EPSKLSMLCH ADSLGILPVQ
   361  WCLKNGVSLT PPKGYSGQDF DWADYHKQHG AQEAPPFCFR NTSFSRGFTK NMKLEAVNPR
   421  NPGELCVASV VSVKGRLMWL HLEGLQTPVP EVIVDVESMD IFPVGWCEAN SYPLTAPHKT
   481  VSQKKRKIAV VQPEKQLPPT VPVKKIPHDL CLFPHLDTTG TVNGKYCCPQ LFINHRCFSG
   541  PYLNKGRIAE LPQSVGPGKC VLVLKEVLSM IINAAYKPGR VLRELQLVED PHWNFQEETL
   601  KAKYRGKTYR AVVKIVRTSD QVANFCRRVC AKLECCPNLF SPVLISENCP ENCSIHTKTK
   661  YTYYYGKRKK ISKPPIGESN PDSGHPKPAR RRKRRKSIFV QKKRRSSAVD FTAGSGEESE
   721  EEDADAMDDD TASEETGSEL RDDQTDTSSA EVPSARPRRA VTLRSGSEPV RRPPPERTRR
   781  GRGAPAASSA EEGEKCPPTK PEGTEDTKQE EEERLVLESN PLEWTVTDVV RFIKLTDCAP
   841  LAKIFQEQDI DGQALLLLTL PTVQECMELK LGPAIKLCHQ IERVKVAFYA QYAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SFMBT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

16 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.25

gnomAD pLI

1

gnomAD missense Z

1.28

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of DNA-templated transcription
• negative regulation of gene expression

Molecular functions

• chromatin binding
• histone binding
• transcription corepressor activity

Cellular components

• aggresome
• cytosol
• nuclear body
• nuclear speck
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Sterile alpha motif domain
• Mbt repeat domain
• Sterile alpha motif/pointed domain superfamily
• SLED domain
• Scm-like with four MBT domains protein 1/2, SAM domain
• SLED domain superfamily
• Polycomb group and chromatin remodeling factors
• SAM domain (Sterile alpha motif)
• mbt repeat
• SLED domain
• Scm-like with four MBT domains protein 2, first MBT repeat
• Scm-like with four MBT domains protein 2, third MBT repeat
• Scm-like with four MBT domains protein 2, fourth MBT repeat

KeywordsUniProt

• Nucleus
• Repeat
• Repressor

InteractionsUniProt · HPA

Protein binding partners of SFMBT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• YY1
• PHC1
• UBE2O