Seroatlas · Human Serome Atlas

ZHX1

Zinc fingers and homeoboxes protein 1

Also known as: ZHX1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKY1
Gene: ZHX1
Ensembl: ENSG00000165156
Chromosome: 8
Canonical length: 873 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

873 residues, UniProt reviewed canonical sequence.

>Q9UKY1|ZHX1
     1  MASRRKSTTP CMVLASEQDP DLELISDLDE GPPVLTPVEN TRAESISSDE EVHESVDSDN
    61  QQNKKVEGGY ECKYCTFQTP DLNMFTFHVD SEHPNVVLNS SYVCVECNFL TKRYDALSEH
   121  NLKYHPGEEN FKLTMVKRNN QTIFEQTIND LTFDGSFVKE ENAEQAESTE VSSSGISISK
   181  TPIMKMMKNK VENKRIAVHH NSVEDVPEEK ENEIKPDREE IVENPSSSAS ESNTSTSIVN
   241  RIHPSTASTV VTPAAVLPGL AQVITAVSAQ QNSNLIPKVL IPVNSIPTYN AALDNNPLLL
   301  NTYNKFPYPT MSEITVLSAQ AKYTEEQIKI WFSAQRLKHG VSWTPEEVEE ARRKQFNGTV
   361  HTVPQTITVI PTHISTGSNG LPSILQTCQI VGQPGLVLTQ VAGTNTLPVT APIALTVAGV
   421  PSQNNIQKSQ VPAAQPTAET KPATAAVPTS QSVKHETALV NPDSFGIRAK KTKEQLAELK
   481  VSYLKNQFPH DSEIIRLMKI TGLTKGEIKK WFSDTRYNQR NSKSNQCLHL NNDSSTTIII
   541  DSSDETTESP TVGTAQPKQS WNPFPDFTPQ KFKEKTAEQL RVLQASFLNS SVLTDEELNR
   601  LRAQTKLTRR EIDAWFTEKK KSKALKEEKM EIDESNAGSS KEEAGETSPA DESGAPKSGS
   661  TGKICKKTPE QLHMLKSAFV RTQWPSPEEY DKLAKESGLA RTDIVSWFGD TRYAWKNGNL
   721  KWYYYYQSAN SSSMNGLSSL RKRGRGRPKG RGRGRPRGRP RGSKRINNWD RGPSLIKFKT
   781  GTAILKDYYL KHKFLNEQDL DELVNKSHMG YEQVREWFAE RQRRSELGIE LFEENEEEDE
   841  VIDDQEEDEE ETDDSDTWEP PRHVKRKLSK SDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZHX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

liver: 37 nTPM
thyroid gland: 35 nTPM
esophagus: 35 nTPM
retina: 32 nTPM
adipose tissue: 27 nTPM
skin: 26 nTPM

Single-cell type

late spermatids: 14 nCPM
cardiomyocytes: 11 nCPM
prostatic club cells: 6.3 nCPM
suprabasal keratinocytes: 5 nCPM
prostatic hillock cells: 4.7 nCPM
epicardial cells: 4.5 nCPM

Immune cell

non-classical monocyte: 14 nTPM
NK-cell: 6.5 nTPM
intermediate monocyte: 6.4 nTPM
T-reg: 5.7 nTPM
myeloid DC: 4.9 nTPM
MAIT T-cell: 4.8 nTPM

Brain region

hypothalamus: 62 nTPM
white matter: 54 nTPM
midbrain: 52 nTPM
cerebellum: 50 nTPM
medulla oblongata: 49 nTPM
amygdala: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.8
gnomAD missense Z: 1.96
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZHX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZHX1 as an antibody target. Whether an autoantibody or antibody against ZHX1 could matter depends on whether native ZHX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZHX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZHX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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