Seroatlas · Human Serome Atlas

PARP3

Protein mono-ADP-ribosyltransferase PARP3

Also known as: ADPRT3, ADPRTL3, ARTD3, hPARP-3, IRT1, pADPRT-3, PARP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6F1
Gene
PARP3
Ensembl
ENSG00000041880
Chromosome
3
Canonical length
533 aa
Protein class
FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

533 residues, UniProt reviewed canonical sequence.

>Q9Y6F1|PARP3
     1  MAPKPKPWVQ TEGPEKKKGR QAGREEDPFR STAEALKAIP AEKRIIRVDP TCPLSSNPGT
    61  QVYEDYNCTL NQTNIENNNN KFYIIQLLQD SNRFFTCWNR WGRVGEVGQS KINHFTRLED
   121  AKKDFEKKFR EKTKNNWAER DHFVSHPGKY TLIEVQAEDE AQEAVVKVDR GPVRTVTKRV
   181  QPCSLDPATQ KLITNIFSKE MFKNTMALMD LDVKKMPLGK LSKQQIARGF EALEALEEAL
   241  KGPTDGGQSL EELSSHFYTV IPHNFGHSQP PPINSPELLQ AKKDMLLVLA DIELAQALQA
   301  VSEQEKTVEE VPHPLDRDYQ LLKCQLQLLD SGAPEYKVIQ TYLEQTGSNH RCPTLQHIWK
   361  VNQEGEEDRF QAHSKLGNRK LLWHGTNMAV VAAILTSGLR IMPHSGGRVG KGIYFASENS
   421  KSAGYVIGMK CGAHHVGYMF LGEVALGREH HINTDNPSLK SPPPGFDSVI ARGHTEPDPT
   481  QDTELELDGQ QVVVPQGQPV PCPEFSSSTF SQSEYLIYQE SQCRLRYLLE VHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 34 nTPM
  • adrenal gland: 33 nTPM
  • liver: 29 nTPM
  • duodenum: 27 nTPM
  • small intestine: 24 nTPM
  • kidney: 22 nTPM

Single-cell type

  • enterocytes: 31 nCPM
  • foveolar cells: 22 nCPM
  • late spermatids: 21 nCPM
  • adrenal cortex cells: 18 nCPM
  • epididymal basal cells: 18 nCPM
  • enteric stem cells: 17 nCPM

Immune cell

  • memory B-cell: 6.4 nTPM
  • NK-cell: 5.7 nTPM
  • naive CD4 T-cell: 3.6 nTPM
  • naive CD8 T-cell: 3.5 nTPM
  • T-reg: 3.2 nTPM
  • intermediate monocyte: 3 nTPM

Brain region

  • thalamus: 19 nTPM
  • midbrain: 18 nTPM
  • choroid plexus: 17 nTPM
  • hypothalamus: 17 nTPM
  • medulla oblongata: 16 nTPM
  • pons: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PARP3.

Disease | ImmuneIEDB

Conditions an epitope on PARP3 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.24
gnomAD pLI
0
gnomAD missense Z
0.31
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PARP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARP3 as an antibody target. Whether an autoantibody or antibody against PARP3 could matter depends on whether native PARP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PARP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PARP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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