Seroatlas · Human Serome Atlas

ARHGAP19

Rho GTPase-activating protein 19

Also known as: FLJ00194, MGC14258, RHG19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14CB8
Gene
ARHGAP19
Ensembl
ENSG00000213390
Chromosome
10
Canonical length
494 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

494 residues, UniProt reviewed canonical sequence.

>Q14CB8|ARHGAP19
     1  MATEAQSEGE VPARESGRSD AICSFVICND SSLRGQPIIF NPDFFVEKLR HEKPEIFTEL
    61  VVSNITRLID LPGTELAQLM GEVDLKLPGG AGPASGFFRS LMSLKRKEKG VIFGSPLTEE
   121  GIAQIYQLIE YLHKNLRVEG LFRVPGNSVR QQILRDALNN GTDIDLESGE FHSNDVATLL
   181  KMFLGELPEP LLTHKHFNAH LKIADLMQFD DKGNKTNIPD KDRQIEALQL LFLILPPPNR
   241  NLLKLLLDLL YQTAKKQDKN KMSAYNLALM FAPHVLWPKN VTANDLQENI TKLNSGMAFM
   301  IKHSQKLFKA PAYIRECARL HYLGSRTQAS KDDLDLIASC HTKSFQLAKS QKRNRVDSCP
   361  HQEETQHHTE EALRELFQHV HDMPESAKKK QLIRQFNKQS LTQTPGREPS TSQVQKRARS
   421  RSFSGLIKRK VLGNQMMSEK KKKNPTPESV AIGELKGTSK ENRNLLFSGS PAVTMTPTRL
   481  KWSEGKKEGK KGFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 20 nTPM
  • bone marrow: 18 nTPM
  • testis: 17 nTPM
  • lymph node: 12 nTPM
  • tonsil: 12 nTPM
  • spleen: 7.4 nTPM

Single-cell type

  • oocytes: 4.6 nCPM
  • erythrocyte progenitors: 3.6 nCPM
  • early spermatids: 3 nCPM
  • erythrocytes: 3 nCPM
  • late spermatids: 2.8 nCPM
  • monocyte progenitors: 2.8 nCPM

Immune cell

  • basophil: 22 nTPM
  • neutrophil: 16 nTPM
  • eosinophil: 11 nTPM
  • classical monocyte: 7.2 nTPM
  • intermediate monocyte: 6.8 nTPM
  • T-reg: 6.4 nTPM

Brain region

  • white matter: 15 nTPM
  • medulla oblongata: 13 nTPM
  • basal ganglia: 12 nTPM
  • pons: 10 nTPM
  • spinal cord: 10 nTPM
  • hypothalamus: 10 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARHGAP19.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 72 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Charcot-Marie-Tooth disease, axonal, type 2KK

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
0.34
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGAP19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP19 as an antibody target. Whether an autoantibody or antibody against ARHGAP19 could matter depends on whether native ARHGAP19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGAP19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARHGAP19. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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