Seroatlas · Human Serome Atlas

IFITM3

Interferon-induced transmembrane protein 3

Also known as: 1-8U, DSPA2b, IFM3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q01628
Gene: IFITM3
Ensembl: ENSG00000142089
Chromosome: 11
Canonical length: 133 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]

Canonical amino-acid sequenceUniProt

133 residues, UniProt reviewed canonical sequence.

>Q01628|IFITM3
     1  MNHTVQTFFS PVNSGQPPNY EMLKEEHEVA VLGAPHNPAP PTSTVIHIRS ETSVPDHVVW
    61  SLFNTLFMNP CCLGFIAFAY SVKSRDRKMV GDVTGAQAYA STAKCLNIWA LILGILMTIL
   121  LIVIPVLIFQ AYG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFITM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 3,362 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 3,362 nTPM
liver: 3,237 nTPM
blood vessel: 2,757 nTPM
adipose tissue: 2,491 nTPM
fallopian tube: 2,476 nTPM
lung: 2,136 nTPM

Single-cell type

decidual stromal cells: 3,820 nCPM
fallopian secretory cells: 2,246 nCPM
hepatocytes: 1,917 nCPM
epididymal efferent duct absorptive cells: 1,851 nCPM
hepatic stellate cells: 1,678 nCPM
vascular endothelial cells: 1,570 nCPM

Immune cell

non-classical monocyte: 3,364 nTPM
neutrophil: 2,953 nTPM
intermediate monocyte: 2,752 nTPM
NK-cell: 929 nTPM
total PBMC: 929 nTPM
classical monocyte: 742 nTPM

Brain region

medulla oblongata: 537 nTPM
hypothalamus: 513 nTPM
thalamus: 509 nTPM
choroid plexus: 501 nTPM
pons: 440 nTPM
midbrain: 381 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0.03
gnomAD missense Z: -0.54
DepMap mean gene effect: -1.07
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFITM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFITM3 as an antibody target. Whether an autoantibody or antibody against IFITM3 could matter depends on whether native IFITM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFITM3 is annotated at the cell surface, where native IFITM3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IFITM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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