Seroatlas · Human Serome Atlas

SEC22C

Vesicle-trafficking protein SEC22c

Also known as: MGC13261, MGC5373, SC22C_HUMAN, SEC22L3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRL7
Gene: SEC22C
Ensembl: ENSG00000093183
Chromosome: 3
Canonical length: 303 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the SEC22 family of vesicle trafficking proteins. The encoded protein is localized to the endoplasmic reticulum and may play a role in the early stages of ER-Golgi protein trafficking. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>Q9BRL7|SEC22C
     1  MSVIFFACVV RVRDGLPLSA STDFYHTQDF LEWRRRLKSL ALRLAQYPGR GSAEGCDFSI
    61  HFSSFGDVAC MAICSCQCPA AMAFCFLETL WWEFTASYDT TCIGLASRPY AFLEFDSIIQ
   121  KVKWHFNYVS SSQMECSLEK IQEELKLQPP AVLTLEDTDV ANGVMNGHTP MHLEPAPNFR
   181  MEPVTALGIL SLILNIMCAA LNLIRGVHLA EHSLQVAHEE IGNILAFLVP FVACIFQCYL
   241  YLFYSPARTM KVVLMLLFIC LGNMYLHGLR NLWQILFHIG VAFLSSYQIL TRQLQEKQSD
   301  CGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEC22C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 63 nTPM
blood vessel: 43 nTPM
midbrain: 42 nTPM
prostate: 35 nTPM
bone marrow: 34 nTPM
basal ganglia: 34 nTPM

Single-cell type

cardiomyocytes: 196 nCPM
epicardial cells: 134 nCPM
late primary spermatocytes: 119 nCPM
mast cells: 91 nCPM
erythrocyte progenitors: 87 nCPM
early primary spermatocytes: 79 nCPM

Immune cell

eosinophil: 22 nTPM
MAIT T-cell: 20 nTPM
memory CD4 T-cell: 18 nTPM
T-reg: 16 nTPM
memory CD8 T-cell: 16 nTPM
naive CD4 T-cell: 15 nTPM

Brain region

white matter: 63 nTPM
medulla oblongata: 53 nTPM
pons: 50 nTPM
basal ganglia: 50 nTPM
midbrain: 50 nTPM
cerebellum: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.84
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEC22C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

VAPA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEC22C as an antibody target. Whether an autoantibody or antibody against SEC22C could matter depends on whether native SEC22C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEC22C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEC22C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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