Seroatlas · Human Serome Atlas

OCLN

Occludin

Also known as: OCLN_HUMAN, PPP1R115

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16625
Gene
OCLN
Ensembl
ENSG00000197822
Chromosome
5
Canonical length
522 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Cell Junctions

OverviewNCBI Gene

This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]

Canonical amino-acid sequenceUniProt

522 residues, UniProt reviewed canonical sequence.

>Q16625|OCLN
     1  MSSRPLESPP PYRPDEFKPN HYAPSNDIYG GEMHVRPMLS QPAYSFYPED EILHFYKWTS
    61  PPGVIRILSM LIIVMCIAIF ACVASTLAWD RGYGTSLLGG SVGYPYGGSG FGSYGSGYGY
   121  GYGYGYGYGG YTDPRAAKGF MLAMAAFCFI AALVIFVTSV IRSEMSRTRR YYLSVIIVSA
   181  ILGIMVFIAT IVYIMGVNPT AQSSGSLYGS QIYALCNQFY TPAATGLYVD QYLYHYCVVD
   241  PQEAIAIVLG FMIIVAFALI IFFAVKTRRK MDRYDKSNIL WDKEHIYDEQ PPNVEEWVKN
   301  VSAGTQDVPS PPSDYVERVD SPMAYSSNGK VNDKRFYPES SYKSTPVPEV VQELPLTSPV
   361  DDFRQPRYSS GGNFETPSKR APAKGRAGRS KRTEQDHYET DYTTGGESCD ELEEDWIREY
   421  PPITSDQQRQ LYKRNFDTGL QEYKSLQSEL DEINKELSRL DKELDDYREE SEEYMAAADE
   481  YNRLKQVKGS ADYKSKKNHC KQLKSKLSHI KKMVGDYDRQ KT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OCLN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 29 nTPM
  • liver: 18 nTPM
  • stomach: 14 nTPM
  • lung: 14 nTPM
  • pancreas: 14 nTPM
  • rectum: 10 nTPM

Single-cell type

  • distal convoluted tubule cells: 135 nCPM
  • renal collecting duct intercalated cells: 111 nCPM
  • loop of henle epithelial cells: 96 nCPM
  • papillary tip epithelial cells: 80 nCPM
  • renal connecting tubule cells: 76 nCPM
  • choroid plexus epithelial cells: 63 nCPM

Immune cell

  • neutrophil: 2.6 nTPM
  • basophil: 0.9 nTPM
  • eosinophil: 0.5 nTPM
  • NK-cell: 0.4 nTPM
  • naive B-cell: 0.3 nTPM
  • plasmacytoid DC: 0.3 nTPM

Brain region

  • choroid plexus: 45 nTPM
  • medulla oblongata: 18 nTPM
  • pons: 16 nTPM
  • midbrain: 14 nTPM
  • white matter: 13 nTPM
  • cerebellum: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about OCLN.

Disease | AllUniProt

Conditions OCLN is implicated in, by any mechanism.

Disease | GeneticClinVar

23 pathogenic / likely-pathogenic of 163 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Pseudo-TORCH syndrome 1
  • OCLN-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
0.32
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OCLN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OCLN as an antibody target. Whether an autoantibody or antibody against OCLN could matter depends on whether native OCLN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OCLN is annotated at the cell surface, where native OCLN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OCLN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OCLN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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