Seroatlas · Human Serome Atlas

CAMLG

Guided entry of tail-anchored proteins factor CAMLG

Also known as: CAML, CAMLG_HUMAN, GET2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49069
Gene: CAMLG
Ensembl: ENSG00000164615
Chromosome: 5
Canonical length: 296 aa
Protein class: FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Nucleoli,Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

296 residues, UniProt reviewed canonical sequence.

>P49069|CAMLG
     1  MESMAVATDG GERPGVPAGS GLSASQRRAE LRRRKLLMNS EQRINRIMGF HRPGSGAEEE
    61  SQTKSKQQDS DKLNSLSVPS VSKRVVLGDS VSTGTTDQQG GVAEVKGTQL GDKLDSFIKP
   121  PECSSDVNLE LRQRNRGDLT ADSVQRGSRH GLEQYLSRFE EAMKLRKQLI SEKPSQEDGN
   181  TTEEFDSFRI FRLVGCALLA LGVRAFVCKY LSIFAPFLTL QLAYMGLYKY FPKSEKKIKT
   241  TVLTAALLLS GIPAEVINRS MDTYSKMGEV FTDLCVYFFT FIFCHELLDY WGSEVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAMLG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 79 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 79 nTPM
hypothalamus: 75 nTPM
amygdala: 71 nTPM
midbrain: 66 nTPM
basal ganglia: 62 nTPM
hippocampal formation: 62 nTPM

Single-cell type

late spermatids: 2,733 nCPM
early spermatids: 837 nCPM
late primary spermatocytes: 669 nCPM
oocytes: 290 nCPM
decidual stromal cells: 257 nCPM
ovarian stromal cells: 209 nCPM

Immune cell

basophil: 63 nTPM
eosinophil: 61 nTPM
T-reg: 53 nTPM
neutrophil: 48 nTPM
naive CD4 T-cell: 45 nTPM
non-classical monocyte: 45 nTPM

Brain region

hypothalamus: 33 nTPM
pons: 30 nTPM
midbrain: 29 nTPM
cerebral cortex: 28 nTPM
white matter: 27 nTPM
spinal cord: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CAMLG.

Disease | AllUniProt

Conditions CAMLG is implicated in, by any mechanism.

Congenital disorder of glycosylation 2Z (CDG2Z) MIM:620201

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.65
DepMap mean gene effect: -0.49
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin protein ligase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Guided entry of tail-anchored proteins factor CAMLG
Get2-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAMLG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAMLG as an antibody target. Whether an autoantibody or antibody against CAMLG could matter depends on whether native CAMLG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAMLG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAMLG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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