Seroatlas · Human Serome Atlas

ERGIC3

Endoplasmic reticulum-Golgi intermediate compartment protein 3

Also known as: C20orf47, CGI-54, ERGI3_HUMAN, Erv46, NY-BR-84, PRO0989, SDBCAG84

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y282
Gene: ERGIC3
Ensembl: ENSG00000125991
Chromosome: 20
Canonical length: 383 aa
Protein class: Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and positive regulation of intracellular protein transport. Located in membrane. Part of retrograde transporter complex, Golgi to ER. Biomarker of lung adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

383 residues, UniProt reviewed canonical sequence.

>Q9Y282|ERGIC3
     1  MEALGKLKQF DAYPKTLEDF RVKTCGGATV TIVSGLLMLL LFLSELQYYL TTEVHPELYV
    61  DKSRGDKLKI NIDVLFPHMP CAYLSIDAMD VAGEQQLDVE HNLFKQRLDK DGIPVSSEAE
   121  RHELGKVEVT VFDPDSLDPD RCESCYGAEA EDIKCCNTCE DVREAYRRRG WAFKNPDTIE
   181  QCRREGFSQK MQEQKNEGCQ VYGFLEVNKV AGNFHFAPGK SFQQSHVHVH DLQSFGLDNI
   241  NMTHYIQHLS FGEDYPGIVN PLDHTNVTAP QASMMFQYFV KVVPTVYMKV DGEVLRTNQF
   301  SVTRHEKVAN GLLGDQGLPG VFVLYELSPM MVKLTEKHRS FTHFLTGVCA IIGGMFTVAG
   361  LIDSLIYHSA RAIQKKIDLG KTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERGIC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 523 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 523 nTPM
epididymis: 431 nTPM
fallopian tube: 306 nTPM
pancreas: 255 nTPM
ovary: 220 nTPM
testis: 210 nTPM

Single-cell type

late spermatids: 941 nCPM
early spermatids: 808 nCPM
syncytiotrophoblasts: 706 nCPM
extravillous trophoblasts: 686 nCPM
epididymal principal cells: 579 nCPM
cytotrophoblasts: 567 nCPM

Immune cell

total PBMC: 238 nTPM
myeloid DC: 229 nTPM
plasmacytoid DC: 227 nTPM
classical monocyte: 189 nTPM
intermediate monocyte: 182 nTPM
T-reg: 178 nTPM

Brain region

choroid plexus: 186 nTPM
hypothalamus: 81 nTPM
midbrain: 74 nTPM
medulla oblongata: 72 nTPM
pons: 70 nTPM
thalamus: 69 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ERGIC3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 76 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Developmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 1.55
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ERGIC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERGIC3 as an antibody target. Whether an autoantibody or antibody against ERGIC3 could matter depends on whether native ERGIC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERGIC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERGIC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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