BET1L
BET1-like protein
Also known as: BET1L_HUMAN, GOLIM3, GS15
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NYM9
- Gene
- BET1L
- Ensembl
- ENSG00000177951
- Chromosome
- 11
- Canonical length
- 111 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Golgi apparatus
OverviewNCBI Gene
Enables SNAP receptor activity. Involved in regulation of retrograde vesicle-mediated transport, Golgi to ER and retrograde transport, endosome to Golgi. Located in Golgi apparatus and endosome. Implicated in uterine fibroid. Biomarker of endometrial adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
111 residues, UniProt reviewed canonical sequence.
>Q9NYM9|BET1L
1 MADWARAQSP GAVEEILDRE NKRMADSLAS KVTRLKSLAL DIDRDAEDQN RYLDGMDSDF
61 TSMTSLLTGS VKRFSTMARS GQDNRKLLCG MAVGLIVAFF ILSYFLSRAR TLocalizationUniProt · AlphaFold · HPA
Whether an antibody against BET1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 168 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 168 nTPM
- pancreas: 77 nTPM
- salivary gland: 65 nTPM
- appendix: 58 nTPM
- epididymis: 55 nTPM
- pituitary gland: 54 nTPM
Single-cell type
- late spermatids: 232 nCPM
- late primary spermatocytes: 83 nCPM
- megakaryocytes: 80 nCPM
- breast lactating cells: 69 nCPM
- plasma cells: 66 nCPM
- epididymal principal cells: 62 nCPM
Immune cell
- neutrophil: 90 nTPM
- eosinophil: 68 nTPM
- basophil: 59 nTPM
- naive CD4 T-cell: 39 nTPM
- MAIT T-cell: 35 nTPM
- total PBMC: 34 nTPM
Brain region
- cerebral cortex: 123 nTPM
- choroid plexus: 112 nTPM
- white matter: 109 nTPM
- medulla oblongata: 103 nTPM
- pons: 90 nTPM
- thalamus: 89 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.55
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.14
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- protein transport
- regulation of retrograde vesicle-mediated transport, Golgi to ER
- retrograde transport, endosome to Golgi
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of BET1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads BET1L as an antibody target. Whether an autoantibody or antibody against BET1L could matter depends on whether native BET1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
BET1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label BET1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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