Seroatlas · Human Serome Atlas

ZW10

Centromere/kinetochore protein zw10 homolog

Also known as: KNTC1AP, ZW10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43264
Gene
ZW10
Ensembl
ENSG00000086827
Chromosome
11
Canonical length
779 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

779 residues, UniProt reviewed canonical sequence.

>O43264|ZW10
     1  MASFVTEVLA HSGRLEKEDL GTRISRLTRR VEEIKGEVCN MISKKYSEFL PSMQSAQGLI
    61  TQVDKLSEDI DLLKSRIESE VRRDLHVSTG EFTDLKQQLE RDSVVLSLLK QLQEFSTAIE
   121  EYNCALTEKK YVTGAQRLEE AQKCLKLLKS RKCFDLKILK SLSMELTIQK QNILYHLGEE
   181  WQKLIVWKFP PSKDTSSLES YLQTELHLYT EQSHKEEKTP MPPISSVLLA FSVLGELHSK
   241  LKSFGQMLLK YILRPLASCP SLHAVIESQP NIVIIRFESI MTNLEYPSPS EVFTKIRLVL
   301  EVLQKQLLDL PLDTDLENEK TSTVPLAEML GDMIWEDLSE CLIKNCLVYS IPTNSSKLQQ
   361  YEEIIQSTEE FENALKEMRF LKGDTTDLLK YARNINSHFA NKKCQDVIVA ARNLMTSEIH
   421  NTVKIIPDSK INVPELPTPD EDNKLEVQKV SNTQYHEVMN LEPENTLDQH SFSLPTCRIS
   481  ESVKKLMELA YQTLLEATTS SDQCAVQLFY SVRNIFHLFH DVVPTYHKEN LQKLPQLAAI
   541  HHNNCMYIAH HLLTLGHQFR LRLAPILCDG TATFVDLVPG FRRLGTECFL AQMRAQKGEL
   601  LERLSSARNF SNMDDEENYS AASKAVRQVL HQLKRLGIVW QDVLPVNIYC KAMGTLLNTA
   661  ISEVIGKITA LEDISTEDGD RLYSLCKTVM DEGPQVFAPL SEESKNKKYQ EEVPVYVPKW
   721  MPFKELMMML QASLQEIGDR WADGKGPLAA AFSSSEVKAL IRALFQNTER RAAALAKIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZW10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • skin: 14 nTPM
  • skeletal muscle: 14 nTPM
  • testis: 13 nTPM
  • liver: 12 nTPM
  • thymus: 11 nTPM
  • tongue: 11 nTPM

Single-cell type

  • early primary spermatocytes: 63 nCPM
  • myonuclei: 44 nCPM
  • endometrial glandular cells: 40 nCPM
  • endometrial luminal cells: 38 nCPM
  • late primary spermatocytes: 38 nCPM
  • tuft cells: 35 nCPM

Immune cell

  • intermediate monocyte: 10 nTPM
  • myeloid DC: 9.5 nTPM
  • non-classical monocyte: 9.3 nTPM
  • basophil: 8.6 nTPM
  • MAIT T-cell: 8.5 nTPM
  • classical monocyte: 7.4 nTPM

Brain region

  • white matter: 13 nTPM
  • cerebellum: 11 nTPM
  • midbrain: 11 nTPM
  • pons: 10 nTPM
  • medulla oblongata: 10 nTPM
  • thalamus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0
gnomAD missense Z
0.44
DepMap mean gene effect
-0.28
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Centromere/kinetochore protein zw10, N-terminal
  • Zw10/DSL1, C-terminal
  • Centromere/kinetochore protein zw10, C-terminal domain
  • Centromere/kinetochore protein zw10, middle domain
  • ZW10, C-terminal helical domain
  • Centromere/kinetochore Zw10 N-terminal
  • Centromere/kinetochore protein zw10, middle domain
  • Centromere/kinetochore protein zw10, C-terminal
  • ZW10 C-terminal helical domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZW10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZW10 as an antibody target. Whether an autoantibody or antibody against ZW10 could matter depends on whether native ZW10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZW10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZW10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZW10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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