Seroatlas · Human Serome Atlas

RINT1

RAD50-interacting protein 1

Also known as: FLJ11785, RINT-1, RINT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NUQ1
Gene
RINT1
Ensembl
ENSG00000135249
Chromosome
7
Canonical length
792 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

This gene encodes a protein first identified for its ability to interact with the RAD50 double strand break repair protein, with the resulting interaction implicated in the regulation of cell cycle progression and telomere length. The encoded protein may also play a role in trafficking of cellular cargo from the endosome to the trans-Golgi network. Mutations in this gene may be associated with breast cancer in human patients. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

792 residues, UniProt reviewed canonical sequence.

>Q6NUQ1|RINT1
     1  MLPAGEIGAS PAAPCCSESG DERKNLEEKS DINVTVLIGS KQVSEGTDNG DLPSYVSAFI
    61  EKEVGNDLKS LKKLDKLIEQ RTVSKMQLEE QVLTISSEIP KRIRSALKNA EESKQFLNQF
   121  LEQETHLFSA INSHLLTAQP WMDDLGTMIS QIEEIERHLA YLKWISQIEE LSDNIQQYLM
   181  TNNVPEAAST LVSMAELDIK LQESSCTHLL GFMRATVKFW HKILKDKLTS DFEEILAQLH
   241  WPFIAPPQSQ TVGLSRPASA PEIYSYLETL FCQLLKLQTS DELLTEPKQL PEKYSLPASP
   301  SVILPIQVML TPLQKRFRYH FRGNRQTNVL SKPEWYLAQV LMWIGNHTEF LDEKIQPILD
   361  KVGSLVNARL EFSRGLMMLV LEKLATDIPC LLYDDNLFCH LVDEVLLFER ELHSVHGYPG
   421  TFASCMHILS EETCFQRWLT VERKFALQKM DSMLSSEAAW VSQYKDITDV DEMKVPDCAE
   481  TFMTLLLVIT DRYKNLPTAS RKLQFLELQK DLVDDFRIRL TQVMKEETRA SLGFRYCAIL
   541  NAVNYISTVL ADWADNVFFL QLQQAALEVF AENNTLSKLQ LGQLASMESS VFDDMINLLE
   601  RLKHDMLTRQ VDHVFREVKD AAKLYKKERW LSLPSQSEQA VMSLSSSACP LLLTLRDHLL
   661  QLEQQLCFSL FKIFWQMLVE KLDVYIYQEI ILANHFNEGG AAQLQFDMTR NLFPLFSHYC
   721  KRPENYFKHI KEACIVLNLN VGSALLLKDV LQSASGQLPA TAALNEVGIY KLAQQDVEIL
   781  LNLRTNWPNT GK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RINT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 16 nTPM
  • bone marrow: 14 nTPM
  • tonsil: 13 nTPM
  • lymph node: 13 nTPM
  • tongue: 12 nTPM
  • pancreas: 11 nTPM

Single-cell type

  • myonuclei: 60 nCPM
  • plasma cells: 53 nCPM
  • thymocytes: 46 nCPM
  • erythrocyte progenitors: 42 nCPM
  • pancreatic acinar cells: 42 nCPM
  • esophageal apical cells: 42 nCPM

Immune cell

  • MAIT T-cell: 12 nTPM
  • T-reg: 11 nTPM
  • memory CD4 T-cell: 9.8 nTPM
  • naive CD8 T-cell: 9.4 nTPM
  • memory CD8 T-cell: 9.2 nTPM
  • NK-cell: 9.1 nTPM

Brain region

  • cerebellum: 19 nTPM
  • choroid plexus: 16 nTPM
  • white matter: 13 nTPM
  • cerebral cortex: 12 nTPM
  • hypothalamus: 11 nTPM
  • spinal cord: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RINT1.

Disease | AllUniProt

Conditions RINT1 is implicated in, by any mechanism.

  • Infantile liver failure syndrome 3 (ILFS3) MIM:618641

Disease | GeneticClinVar

43 pathogenic / likely-pathogenic of 1,818 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on RINT1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
gnomAD missense Z
0.83
DepMap mean gene effect
-1.07
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RINT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RINT1 as an antibody target. Whether an autoantibody or antibody against RINT1 could matter depends on whether native RINT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RINT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RINT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RINT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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