Seroatlas · Human Serome Atlas

CALU

Calumenin

Also known as: CALU_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43852
Gene: CALU
Ensembl: ENSG00000128595
Chromosome: 7
Canonical length: 315 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>O43852|CALU
     1  MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT
    61  FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA QKRWIYEDVE RQWKGHDLNE
   121  DGLVSWEEYK NATYGYVLDD PDPDDGFNYK QMMVRDERRF KMADKDGDLI ATKEEFTAFL
   181  HPEEYDYMKD IVVQETMEDI DKNADGFIDL EEYIGDMYSH DGNTDEPEWV KTEREQFVEF
   241  RDKNRDGKMD KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS
   301  QATDFGEALV RHDEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALU can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 334 nTPM

Expression across tissuesHPA

Tissue

smooth muscle: 334 nTPM
heart muscle: 234 nTPM
placenta: 212 nTPM
blood vessel: 177 nTPM
urinary bladder: 161 nTPM
seminal vesicle: 153 nTPM

Single-cell type

extravillous trophoblasts: 898 nCPM
syncytiotrophoblasts: 353 nCPM
decidual stromal cells: 338 nCPM
hepatic stellate cells: 258 nCPM
smooth muscle cells: 253 nCPM
fibroblasts: 246 nCPM

Immune cell

intermediate monocyte: 47 nTPM
classical monocyte: 44 nTPM
non-classical monocyte: 41 nTPM
myeloid DC: 38 nTPM
plasmacytoid DC: 38 nTPM
total PBMC: 36 nTPM

Brain region

choroid plexus: 119 nTPM
thalamus: 63 nTPM
white matter: 46 nTPM
medulla oblongata: 44 nTPM
hypothalamus: 39 nTPM
cerebellum: 39 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CALU.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 47 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Developmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.01
gnomAD missense Z: 1.31
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CALU in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALU as an antibody target. Whether an autoantibody or antibody against CALU could matter depends on whether native CALU is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALU is annotated as secreted, so native CALU circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CALU as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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