KDELR1

Protein identityUniProt · HPA

UniProt accession

P24390

Gene

KDELR1

Ensembl

ENSG00000105438

Chromosome

19

Canonical length

212 aa

Protein class

Predicted membrane proteins, Transporters

Subcellular location

Golgi apparatus,Vesicles,Cytosol

OverviewNCBI Gene

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

212 residues, UniProt reviewed canonical sequence.

>P24390|KDELR1
     1  MNLFRFLGDL SHLLAIILLL LKIWKSRSCA GISGKSQVLF AVVFTARYLD LFTNYISLYN
    61  TCMKVVYIAC SFTTVWLIYS KFKATYDGNH DTFRVEFLVV PTAILAFLVN HDFTPLEILW
   121  TFSIYLESVA ILPQLFMVSK TGEAETITSH YLFALGVYRT LYLFNWIWRY HFEGFFDLIA
   181  IVAGLVQTVL YCDFFYLYIT KVLKGKKLSL PA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KDELR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

180 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KDELR1.

Disease | ImmuneIEDB

Conditions an epitope on KDELR1 was assayed in.

• colonic benign neoplasm T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.42

gnomAD pLI

0.88

gnomAD missense Z

2.32

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• protein retention in ER lumen
• protein transport
• retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
• T cell apoptotic process
• T cell differentiation

Molecular functions

• ER retention sequence binding
• KDEL sequence binding

Cellular components

• cis-Golgi network
• COPI-coated vesicle membrane
• endoplasmic reticulum
• endoplasmic reticulum membrane
• endoplasmic reticulum-Golgi intermediate compartment
• endoplasmic reticulum-Golgi intermediate compartment membrane
• Golgi membrane
• transport vesicle

Protein domainsUniProt · Pfam · InterPro

• ER lumen protein retaining receptor
• ER lumen protein retaining receptor

KeywordsUniProt

• Cytoplasmic vesicle
• Endoplasmic reticulum
• ER-Golgi transport
• Golgi apparatus
• Membrane
• Phosphoprotein
• Protein transport
• Receptor
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of KDELR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ARF1
• TMED2
• ARFGAP1