Seroatlas · Human Serome Atlas

GORASP1

Golgi reassembly-stacking protein 1

Also known as: FLJ23443, GOLPH5, GORS1_HUMAN, GRASP65, P65

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQQ3
Gene: GORASP1
Ensembl: ENSG00000114745
Chromosome: 3
Canonical length: 440 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus
Quaternary structure: Homodimer

OverviewNCBI Gene

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

440 residues, UniProt reviewed canonical sequence.

>Q9BQQ3|GORASP1
     1  MGLGVSAEQP AGGAEGFHLH GVQENSPAQQ AGLEPYFDFI ITIGHSRLNK ENDTLKALLK
    61  ANVEKPVKLE VFNMKTMRVR EVEVVPSNMW GGQGLLGASV RFCSFRRASE QVWHVLDVEP
   121  SSPAALAGLR PYTDYVVGSD QILQESEDFF TLIESHEGKP LKLMVYNSKS DSCREVTVTP
   181  NAAWGGEGSL GCGIGYGYLH RIPTQPPSYH KKPPGTPPPS ALPLGAPPPD ALPPGPTPED
   241  SPSLETGSRQ SDYMEALLQA PGSSMEDPLP GPGSPSHSAP DPDGLPHFME TPLQPPPPVQ
   301  RVMDPGFLDV SGISLLDNSN ASVWPSLPSS TELTTTAVST SGPEDICSSS SSHERGGEAT
   361  WSGSEFEVSF LDSPGAQAQA DHLPQLTLPD SLTSAASPED GLSAELLEAQ AEEEPASTEG
   421  LDTGTEAEGL DSQAQISTTE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GORASP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

liver: 34 nTPM
cerebellum: 31 nTPM
kidney: 31 nTPM
heart muscle: 30 nTPM
prostate: 29 nTPM
pancreas: 29 nTPM

Single-cell type

early spermatids: 129 nCPM
late spermatids: 96 nCPM
bergmann glia: 78 nCPM
esophageal apical cells: 47 nCPM
epicardial cells: 43 nCPM
cardiomyocytes: 36 nCPM

Immune cell

non-classical monocyte: 14 nTPM
myeloid DC: 12 nTPM
intermediate monocyte: 11 nTPM
classical monocyte: 10 nTPM
memory B-cell: 8.9 nTPM
naive B-cell: 7.4 nTPM

Brain region

white matter: 33 nTPM
spinal cord: 26 nTPM
thalamus: 23 nTPM
medulla oblongata: 22 nTPM
cerebellum: 21 nTPM
hypothalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.02
gnomAD missense Z: 0.67
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

metal ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GORASP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GORASP1 as an antibody target. Whether an autoantibody or antibody against GORASP1 could matter depends on whether native GORASP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GORASP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GORASP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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