Seroatlas · Human Serome Atlas

TCF7L2

Transcription factor 7-like 2

Also known as: TCF-4, TCF4, TF7L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQB0
Gene
TCF7L2
Ensembl
ENSG00000148737
Chromosome
10
Canonical length
619 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

619 residues, UniProt reviewed canonical sequence.

>Q9NQB0|TCF7L2
     1  MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN ESETNQNSSS
    61  DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY PGYPFIMIPD LTSPYLPNGS
   121  LSPTARTLHF QSGSTHYSAY KTIEHQIAVQ YLQMKWPLLD VQAGSLQSRQ ALKDARSPSP
   181  AHIVSNKVPV VQHPHHVHPL TPLITYSNEH FTPGNPPPHL PADVDPKTGI PRPPHPPDIS
   241  PYYPLSPGTV GQIPHPLGWL VPQQGQPVYP ITTGGFRHPY PTALTVNASM SRFPPHMVPP
   301  HHTLHTTGIP HPAIVTPTVK QESSQSDVGS LHSSKHQDSK KEEEKKKPHI KKPLNAFMLY
   361  MKEMRAKVVA ECTLKESAAI NQILGRRWHA LSREEQAKYY ELARKERQLH MQLYPGWSAR
   421  DNYGKKKKRK RDKQPGETNE HSECFLNPCL SLPPITDLSA PKKCRARFGL DQQNNWCGPC
   481  RRKKKCVRYI QGEGSCLSPP SSDGSLLDSP PPSPNLLGSP PRDAKSQTEQ TQPLSLSLKP
   541  DPLAHLSMMP PPPALLLAEA THKASALCPN GALDLPPAAL QPAAPSSSIA QPSTSSLHSH
   601  SSLAGTQPQP LSLVTKSLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCF7L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 23 nTPM
  • adipose tissue: 21 nTPM
  • ovary: 20 nTPM
  • breast: 19 nTPM
  • rectum: 19 nTPM
  • stomach: 19 nTPM

Single-cell type

  • foveolar cells: 1,101 nCPM
  • kupffer cells: 1,068 nCPM
  • extravillous trophoblasts: 979 nCPM
  • colonocytes: 890 nCPM
  • adipocytes: 783 nCPM
  • goblet cells: 629 nCPM

Immune cell

  • non-classical monocyte: 62 nTPM
  • intermediate monocyte: 24 nTPM
  • neutrophil: 5.8 nTPM
  • classical monocyte: 3.8 nTPM
  • total PBMC: 2.7 nTPM
  • myeloid DC: 2.1 nTPM

Brain region

  • thalamus: 380 nTPM
  • midbrain: 180 nTPM
  • amygdala: 103 nTPM
  • hypothalamus: 88 nTPM
  • cerebral cortex: 72 nTPM
  • medulla oblongata: 43 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TCF7L2.

Disease | AllUniProt

Conditions TCF7L2 is implicated in, by any mechanism.

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 251 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
1
gnomAD missense Z
2.4
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TCF7L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCF7L2 as an antibody target. Whether an autoantibody or antibody against TCF7L2 could matter depends on whether native TCF7L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCF7L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCF7L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TCF7L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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