Seroatlas · Human Serome Atlas

PLEKHH2

Pleckstrin homology domain-containing family H member 2

Also known as: KIAA2028, PKHH2_HUMAN, PLEKHH1L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVE3
Gene: PLEKHH2
Ensembl: ENSG00000152527
Chromosome: 2
Canonical length: 1493 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable actin binding activity. Predicted to be involved in negative regulation of actin filament depolymerization. Located in several cellular components, including cytosol; lamellipodium; and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1493 residues, UniProt reviewed canonical sequence.

>Q8IVE3|PLEKHH2
     1  MAELSEPEGP VDWKERCVAL ESQLMKFRVQ ASKIRELLAE KMQQLERQVI DAERQAEKAF
    61  QQVQVMEDKL KAANIQTSES ETRLYNKCQD LESLIQEKDD VIQNLELQLE EQKQIRIQEA
   121  KIIEEKAAKI KEWVTVKLNE LELENQNLRL INQNQTEEIR TMQSKLQEVQ GKKSSTVSTL
   181  KLSEGQRLSS LTFGCFLSRA RSPPQVVKSE EMSKISSKEP EFTEGKDMEE MEIPEKSVDN
   241  QVLENNRGQR TLHQTPCGSE QNRKTRTSFA TDGGISQNSG APVSDWSSDE EDGSKGRSKS
   301  RCTSTLSSHT SEEGVQCSRM GSEMYLTASD DSSSIFEEET FGIKRPEHKK LYSWQQEAQW
   361  KALNSPLGKG NSELSKKEQD SSSDELNKKF QSQRLDYSSS SSEANTPSPI LTPALMPKHP
   421  NSLSGKGTQL VPSSHLPPPK LRIPNVFSIS VALAKRHLSQ PQLSSDRMFG TNRNAISMIR
   481  PLRPQETDLD LVDGDSTEVL ENMDTSCDDG LFSYDSLDSP NSDDQEHCDS AKKVAYSKPP
   541  TPPLHRFPSW ESRIYAVAKS GIRMSEAFNM ESVNKNSAAT LSYTTSGLYT SLIYKNMTTP
   601  VYTTLKGKAT QISSSPFLDD SSGSEEEDSS RSSSRTSESD SRSRSGPGSP RAMKRGVSLS
   661  SVASESDYAI PPDAYSTDTE YSQPEQKLPK TCSSSSDNGK NEPLEKSGYL LKMSGKVKSW
   721  KRRWFVLKGG ELLYYKSPSD VIRKPQGHIE LSASCSILRG DNKQTVQLTT EKHTYYLTAD
   781  SPNILEEWIK VLQNVLRVQA ANPLSLQPEG KPTMKGLLTK VKHGYSKRVW CTLIGKTLYY
   841  FRSQEDKFPL GQIKLWEAKV EEVDRSCDSD EDYEASGRSL LSTHYTIVIH PKDQGPTYLL
   901  IGSKHEKDTW LYHLTVAAGS NNVNVGSEFE QLVCKLLNID GEPSSQIWRH PTLCHSKEGI
   961  ISPLTTLPSE ALQTEAIKLF KTCQLFINAA VDSPAIDYHI SLAQSALQIC LTHPELQNEI
  1021  CCQLIKQTRR RQPQNQPGPL QGWQLLALCV GLFLPHHPFL WLLRLHLKRN ADSRTEFGKY
  1081  AIYCQRCVER TQQNGDREAR PSRMEILSTL LRNPYHHSLP FSIPVHFMNG IYQVVGFDAS
  1141  TTVEEFLNTL NQDTGMRKPA QSGFALFTDD PSGRDLEHCL QGNIKICDII SKWEQASKEQ
  1201  QPGKCEGTRT VRLTYKNRLY FSVQARGETD REKLLLMYQT NDQIINGLFP LNKDLALEMA
  1261  ALLSQVEIGD FERPFSTPAG HVTNQCKVNQ TLKQVIEKFY PKRYRDGCSE EQLRQLCQRL
  1321  STRWMALRGH SAADCVRIYL TVARKWPFFG AKLFLAKPIT PSSLGSTFLW LAVHEDGLSL
  1381  LEYNSMRLIV SYVYKSLMTF GGYQDDFMVV INNTHSKDKP TEKLLFAMAK PKILEITLLI
  1441  ASYINNFHQQ KAAFHHLSAP ALLSAQTRGP QARMMGSQPL LSSSRPTKGP TLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

lung: 26 nTPM
ovary: 22 nTPM
cervix: 20 nTPM
endometrium: 19 nTPM
fallopian tube: 15 nTPM
kidney: 14 nTPM

Single-cell type

bergmann glia: 529 nCPM
oligodendrocyte progenitor cells: 316 nCPM
decidual stromal cells: 299 nCPM
endometrial stromal cells: 293 nCPM
fibro-adipogenic progenitors: 275 nCPM
podocytes: 220 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 20 nTPM
cerebellum: 8.1 nTPM
midbrain: 8.1 nTPM
pons: 7.3 nTPM
medulla oblongata: 7.2 nTPM
cerebral cortex: 6.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0
gnomAD missense Z: -1.72
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of actin filament depolymerization

Molecular functions

actin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLEKHH2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHH2 as an antibody target. Whether an autoantibody or antibody against PLEKHH2 could matter depends on whether native PLEKHH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHH2 is annotated at the cell surface, where native PLEKHH2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLEKHH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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