Seroatlas · Human Serome Atlas

PARVA

Alpha-parvin

Also known as: FLJ10793, FLJ12254, MXRA2, PARVA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NVD7
Gene
PARVA
Ensembl
ENSG00000197702
Chromosome
11
Canonical length
372 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Actin filaments,Focal adhesion sites,Cytosol

OverviewNCBI Gene

This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>Q9NVD7|PARVA
     1  MATSPQKSPS VPKSPTPKSP PSRKKDDSFL GKLGGTLARR KKAKEVSELQ EEGMNAINLP
    61  LSPIPFELDP EDTMLEENEV RTMVDPNSRS DPKLQELMKV LIDWINDVLV GERIIVKDLA
   121  EDLYDGQVLQ KLFEKLESEK LNVAEVTQSE IAQKQKLQTV LEKINETLKL PPRSIKWNVD
   181  SVHAKSLVAI LHLLVALSQY FRAPIRLPDH VSIQVVVVQK REGILQSRQI QEEITGNTEA
   241  LSGRHERDAF DTLFDHAPDK LNVVKKTLIT FVNKHLNKLN LEVTELETQF ADGVYLVLLM
   301  GLLEGYFVPL HSFFLTPDSF EQKVLNVSFA FELMQDGGLE KPKPRPEDIV NCDLKSTLRV
   361  LYNLFTKYRN VE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARVA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
89 nTPM

Expression across tissuesHPA

Tissue

  • smooth muscle: 89 nTPM
  • colon: 77 nTPM
  • seminal vesicle: 65 nTPM
  • endometrium: 60 nTPM
  • adipose tissue: 58 nTPM
  • cervix: 51 nTPM

Single-cell type

  • podocytes: 463 nCPM
  • pituitary stem cells: 402 nCPM
  • smooth muscle cells: 386 nCPM
  • adipocytes: 332 nCPM
  • decidual stromal cells: 282 nCPM
  • alveolar cells type 1: 279 nCPM

Immune cell

  • MAIT T-cell: 1 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • gdT-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • choroid plexus: 33 nTPM
  • hypothalamus: 23 nTPM
  • spinal cord: 23 nTPM
  • medulla oblongata: 22 nTPM
  • white matter: 21 nTPM
  • cerebral cortex: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.41
gnomAD missense Z
1
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PARVA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARVA as an antibody target. Whether an autoantibody or antibody against PARVA could matter depends on whether native PARVA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARVA is annotated at the cell surface, where native PARVA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PARVA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PARVA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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