Seroatlas · Human Serome Atlas

CRIP2

Cysteine-rich protein 2

Also known as: CRIP2_HUMAN, CRP2, ESP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P52943
Gene: CRIP2
Ensembl: ENSG00000182809
Chromosome: 14
Canonical length: 208 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Plasma membrane

OverviewNCBI Gene

This gene encodes a putative transcription factor with two LIM zinc-binding domains. The encoded protein may participate in the differentiation of smooth muscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>P52943|CRIP2
     1  MASKCPKCDK TVYFAEKVSS LGKDWHKFCL KCERCSKTLT PGGHAEHDGK PFCHKPCYAT
    61  LFGPKGVNIG GAGSYIYEKP LAEGPQVTGP IEVPAARAEE RKASGPPKGP SRASSVTTFT
   121  GEPNTCPRCS KKVYFAEKVT SLGKDWHRPC LRCERCGKTL TPGGHAEHDG QPYCHKPCYG
   181  ILFGPKGVNT GAVGSYIYDR DPEGKVQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 1,152 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 1,152 nTPM
blood vessel: 642 nTPM
cerebral cortex: 258 nTPM
kidney: 232 nTPM
amygdala: 231 nTPM
basal ganglia: 219 nTPM

Single-cell type

esophageal apical cells: 803 nCPM
vascular smooth muscle cells: 379 nCPM
vascular endothelial cells: 365 nCPM
lymphatic endothelial cells: 337 nCPM
epididymal principal cells: 267 nCPM
fallopian secretory cells: 247 nCPM

Immune cell

T-reg: 116 nTPM
naive B-cell: 111 nTPM
memory CD4 T-cell: 81 nTPM
memory B-cell: 52 nTPM
naive CD4 T-cell: 18 nTPM
memory CD8 T-cell: 17 nTPM

Brain region

hypothalamus: 208 nTPM
cerebral cortex: 169 nTPM
hippocampal formation: 167 nTPM
basal ganglia: 164 nTPM
thalamus: 154 nTPM
midbrain: 143 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 0
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

cell cortex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CRIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TGFB1I1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRIP2 as an antibody target. Whether an autoantibody or antibody against CRIP2 could matter depends on whether native CRIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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