PTPN2
Tyrosine-protein phosphatase non-receptor type 2
Also known as: PTN2_HUMAN, PTPT, TC-PTP, TCELLPTP, TCPTP
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P17706
- Gene
- PTPN2
- Ensembl
- ENSG00000175354
- Chromosome
- 18
- Canonical length
- 415 aa
- Protein class
- Enzymes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
Canonical amino-acid sequenceUniProt
415 residues, UniProt reviewed canonical sequence.
>P17706|PTPN2
1 MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD VSPYDHSRVK
61 LQNAENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM VWQQKTKAVV MLNRIVEKES
121 VKCAQYWPTD DQEMLFKETG FSVKLLSEDV KSYYTVHLLQ LENINSGETR TISHFHYTTW
181 PDFGVPESPA SFLNFLFKVR ESGSLNPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGD
241 DINIKQVLLN MRKYRMGLIQ TPDQLRFSYM AIIEGAKCIK GDSSIQKRWK ELSKEDLSPA
301 FDHSPNKIMT EKYNGNRIGL EEEKLTGDRC TGLSSKMQDT MEENSESALR KRIREDRKAT
361 TAQKVQQMKQ RLNENERKRK RWLYWQPILT KMGFMSVILV GAFVGWTLFF QQNALLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PTPN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 93 nTPM
Expression across tissuesHPA
Tissue
- thymus: 93 nTPM
- bone marrow: 54 nTPM
- lymph node: 41 nTPM
- tonsil: 41 nTPM
- urinary bladder: 35 nTPM
- choroid plexus: 32 nTPM
Single-cell type
- plasma cells: 302 nCPM
- monocytes: 283 nCPM
- urothelial cells: 275 nCPM
- pdcs: 255 nCPM
- endometrial glandular cells: 231 nCPM
- respiratory ionocytes: 216 nCPM
Immune cell
- NK-cell: 64 nTPM
- myeloid DC: 63 nTPM
- T-reg: 58 nTPM
- memory B-cell: 55 nTPM
- plasmacytoid DC: 53 nTPM
- classical monocyte: 53 nTPM
Brain region
- cerebellum: 41 nTPM
- choroid plexus: 30 nTPM
- white matter: 26 nTPM
- medulla oblongata: 24 nTPM
- cerebral cortex: 22 nTPM
- pons: 22 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.18
- gnomAD pLI
- 1
- gnomAD missense Z
- 1.38
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- B cell differentiation
- erythrocyte differentiation
- glucose homeostasis
- insulin receptor recycling
- insulin receptor signaling pathway
- negative regulation of cell population proliferation
- negative regulation of chemotaxis
- negative regulation of epidermal growth factor receptor signaling pathway
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of inflammatory response
- negative regulation of insulin receptor signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of lipid storage
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of macrophage differentiation
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway
- negative regulation of receptor signaling pathway via JAK-STAT
- negative regulation of T cell receptor signaling pathway
- negative regulation of transcription by RNA polymerase II
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of tyrosine phosphorylation of STAT protein
- peptidyl-tyrosine dephosphorylation
- positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
- positive regulation of gluconeogenesis
- positive regulation of PERK-mediated unfolded protein response
- regulation of hepatocyte growth factor receptor signaling pathway
- regulation of type II interferon-mediated signaling pathway
- T cell differentiation
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of positive thymic T cell selection
Molecular functions
- integrin binding
- non-membrane spanning protein tyrosine phosphatase activity
- protein kinase binding
- protein tyrosine phosphatase activity
- receptor tyrosine kinase binding
- STAT family protein binding
- syntaxin binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Tyrosine-specific protein phosphatase, PTPase domain
- Tyrosine-specific protein phosphatases domain
- Protein-tyrosine phosphatase, catalytic
- Protein-tyrosine phosphatase, non-receptor type-1/2
- Protein-tyrosine phosphatase, active site
- Protein-tyrosine phosphatase-like
- Non-receptor type tyrosine-specific phosphatase
- Protein-tyrosine phosphatase
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PTPN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PTPN2 as an antibody target. Whether an autoantibody or antibody against PTPN2 could matter depends on whether native PTPN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PTPN2 is annotated at the cell surface, where native PTPN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label PTPN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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