Seroatlas · Human Serome Atlas

GRIPAP1

GRIP1-associated protein 1

Also known as: DKFZp434P0630, GRAP1_HUMAN, GRASP-1, GRASP1, KIAA1167, MPMGp800B12492Q3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4V328
Gene: GRIPAP1
Ensembl: ENSG00000068400
Chromosome: X
Canonical length: 841 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

841 residues, UniProt reviewed canonical sequence.

>Q4V328|GRIPAP1
     1  MAQALSEEEF QRMQAQLLEL RTNNYQLSDE LRKNGVELTS LRQKVAYLDK EFSKAQKALS
    61  KSKKAQEVEV LLSENEMLQA KLHSQEEDFR LQNSTLMAEF SKLCSQMEQL EQENQQLKEG
   121  AAGAGVAQAG PLVDGELLRL QAENTALQKN VAALQERYGK EAGKFSAVSE GQGDPPGGLA
   181  PTVLAPMPLA EVELKWEMEK EEKRLLWEQL QGLESSKQAE TSRLQEELAK LSEKLKKKQE
   241  SFCRLQTEKE TLFNDSRNKI EELQQRKEAD HKAQLARTQK LQQELEAANQ SLAELRDQRQ
   301  GERLEHAAAL RALQDQVSIQ SADAQEQVEG LLAENNALRT SLAALEQIQT AKTQELNMLR
   361  EQTTGLAAEL QQQQAEYEDL MGQKDDLNSQ LQESLRANSR LLEQLQEIGQ EKEQLTQELQ
   421  EARKSAEKRK AMLDELAMET LQEKSQHKEE LGAVRLRHEK EVLGVRARYE RELRELHEDK
   481  KRQEEELRGQ IREEKARTRE LETLQQTVEE LQAQVHSMDG AKGWFERRLK EAEESLQQQQ
   541  QEQEEALKQC REQHAAELKG KEEELQDVRD QLEQAQEERD CHLKTISSLK QEVKDTVDGQ
   601  RILEKKGSAA LKDLKRQLHL ERKRADKLQE RLQDILTNSK SRSGLEELVL SEMNSPSRTQ
   661  TGDSSSISSF SYREILREKE SSAVPARSLS SSPQAQPPRP AELSDEEVAE LFQRLAETQQ
   721  EKWMLEEKVK HLEVSSASMA EDLCRKSAII ETYVMDSRID VSVAAGHTDR SGLGSVLRDL
   781  VKPGDENLRE MNKKLQNMLE EQLTKNMHLH KDMEVLSQEI VRLSKECVGP PDPDLEPGET
   841  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRIPAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 69 nTPM
cerebral cortex: 48 nTPM
basal ganglia: 40 nTPM
hypothalamus: 38 nTPM
midbrain: 38 nTPM
amygdala: 34 nTPM

Single-cell type

cone photoreceptor cells: 137 nCPM
rod photoreceptor cells: 124 nCPM
neutrophils: 91 nCPM
neutrophil progenitors: 78 nCPM
retinal ganglion cells: 77 nCPM
sertoli cells: 76 nCPM

Immune cell

basophil: 22 nTPM
neutrophil: 17 nTPM
eosinophil: 16 nTPM
classical monocyte: 13 nTPM
intermediate monocyte: 12 nTPM
NK-cell: 12 nTPM

Brain region

hypothalamus: 42 nTPM
white matter: 37 nTPM
medulla oblongata: 37 nTPM
midbrain: 36 nTPM
pons: 36 nTPM
cerebral cortex: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 2.62
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein transport
regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
negative regulation of receptor clustering
regulation of recycling endosome localization within postsynapse

Molecular functions

Cellular components

axon
blood microparticle
cytosol
dendrite
glutamatergic synapse
neuronal cell body
nucleoplasm
presynaptic membrane
recycling endosome membrane
extrinsic component of postsynaptic early endosome membrane

Protein domainsUniProt · Pfam · InterPro

GRIP1-associated protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GRIPAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRIPAP1 as an antibody target. Whether an autoantibody or antibody against GRIPAP1 could matter depends on whether native GRIPAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRIPAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GRIPAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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