Seroatlas · Human Serome Atlas

SIN3A

Paired amphipathic helix protein Sin3a

Also known as: DKFZP434K2235, KIAA0700, SIN3A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96ST3
Gene: SIN3A
Ensembl: ENSG00000169375
Chromosome: 15
Canonical length: 1273 aa
Protein class: Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1273 residues, UniProt reviewed canonical sequence.

>Q96ST3|SIN3A
     1  MKRRLDDQES PVYAAQQRRI PGSTEAFPHQ HRVLAPAPPV YEAVSETMQS ATGIQYSVTP
    61  SYQVSAMPQS SGSHGPAIAA VHSSHHHPTA VQPHGGQVVQ SHAHPAPPVA PVQGQQQFQR
   121  LKVEDALSYL DQVKLQFGSQ PQVYNDFLDI MKEFKSQSID TPGVISRVSQ LFKGHPDLIM
   181  GFNTFLPPGY KIEVQTNDMV NVTTPGQVHQ IPTHGIQPQP QPPPQHPSQP SAQSAPAPAQ
   241  PAPQPPPAKV SKPSQLQAHT PASQQTPPLP PYASPRSPPV QPHTPVTISL GTAPSLQNNQ
   301  PVEFNHAINY VNKIKNRFQG QPDIYKAFLE ILHTYQKEQR NAKEAGGNYT PALTEQEVYA
   361  QVARLFKNQE DLLSEFGQFL PDANSSVLLS KTTAEKVDSV RNDHGGTVKK PQLNNKPQRP
   421  SQNGCQIRRH PTGTTPPVKK KPKLLNLKDS SMADASKHGG GTESLFFDKV RKALRSAEAY
   481  ENFLRCLVIF NQEVISRAEL VQLVSPFLGK FPELFNWFKN FLGYKESVHL ETYPKERATE
   541  GIAMEIDYAS CKRLGSSYRA LPKSYQQPKC TGRTPLCKEV LNDTWVSFPS WSEDSTFVSS
   601  KKTQYEEHIY RCEDERFELD VVLETNLATI RVLEAIQKKL SRLSAEEQAK FRLDNTLGGT
   661  SEVIHRKALQ RIYADKAADI IDGLRKNPSI AVPIVLKRLK MKEEEWREAQ RGFNKVWREQ
   721  NEKYYLKSLD HQGINFKQND TKVLRSKSLL NEIESIYDER QEQATEENAG VPVGPHLSLA
   781  YEDKQILEDA AALIIHHVKR QTGIQKEDKY KIKQIMHHFI PDLLFAQRGD LSDVEEEEEE
   841  EMDVDEATGA VKKHNGVGGS PPKSKLLFSN TAAQKLRGMD EVYNLFYVNN NWYIFMRLHQ
   901  ILCLRLLRIC SQAERQIEEE NREREWEREV LGIKRDKSDS PAIQLRLKEP MDVDVEDYYP
   961  AFLDMVRSLL DGNIDSSQYE DSLREMFTIH AYIAFTMDKL IQSIVRQLQH IVSDEICVQV
  1021  TDLYLAENNN GATGGQLNTQ NSRSLLESTY QRKAEQLMSD ENCFKLMFIQ SQGQVQLTIE
  1081  LLDTEEENSD DPVEAERWSD YVERYMNSDT TSPELREHLA QKPVFLPRNL RRIRKCQRGR
  1141  EQQEKEGKEG NSKKTMENVD SLDKLECRFK LNSYKMVYVI KSEDYMYRRT ALLRAHQSHE
  1201  RVSKRLHQRF QAWVDKWTKE HVPREMAAET SKWLMGEGLE GLVPCTTTCD TETLHFVSIN
  1261  KYRVKYGTVF KAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIN3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

thymus: 38 nTPM
bone marrow: 33 nTPM
blood vessel: 23 nTPM
ovary: 23 nTPM
thyroid gland: 23 nTPM
testis: 23 nTPM

Single-cell type

neutrophils: 245 nCPM
salivary myoepithelial cells: 146 nCPM
salivary basal cells: 124 nCPM
neutrophil progenitors: 115 nCPM
endometrial luminal cells: 106 nCPM
respiratory basal cells: 93 nCPM

Immune cell

MAIT T-cell: 7 nTPM
T-reg: 5.8 nTPM
memory CD8 T-cell: 5.6 nTPM
memory CD4 T-cell: 4.9 nTPM
naive CD4 T-cell: 4.8 nTPM
non-classical monocyte: 4.8 nTPM

Brain region

cerebellum: 44 nTPM
hypothalamus: 35 nTPM
medulla oblongata: 34 nTPM
midbrain: 33 nTPM
choroid plexus: 32 nTPM
cerebral cortex: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SIN3A.

Disease | AllUniProt

Conditions SIN3A is implicated in, by any mechanism.

Witteveen-Kolk syndrome (WITKOS) MIM:613406

Disease | GeneticClinVar

113 pathogenic / likely-pathogenic of 803 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

SIN3A-related intellectual disability syndrome due to a point mutation
Inborn genetic diseases
SIN3A-related intellectual disability syndrome
SIN3A-related disorder
See cases

Disease | ImmuneIEDB

Conditions an epitope on SIN3A was assayed in.

glioblastoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.07
gnomAD pLI: 1
gnomAD missense Z: 4.39
DepMap mean gene effect: -1.1
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIN3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIN3A as an antibody target. Whether an autoantibody or antibody against SIN3A could matter depends on whether native SIN3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIN3A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SIN3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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