Seroatlas · Human Serome Atlas

SINHCAF

SIN3-HDAC complex-associated factor

Also known as: C12orf14, FAM60A, SHCAF_HUMAN, TERA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NP50
Gene: SINHCAF
Ensembl: ENSG00000139146
Chromosome: 12
Canonical length: 221 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Involved in negative regulation of cell migration. Part of Sin3-type complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>Q9NP50|SINHCAF
     1  MFGFHKPKMY RSIEGCCICR AKSSSSRFTD SKRYEKDFQS CFGLHETRSG DICNACVLLV
    61  KRWKKLPAGS KKNWNHVVDA RAGPSLKTTL KPKKVKTLSG NRIKSNQISK LQKEFKRHNS
   121  DAHSTTSSAS PAQSPCYSNQ SDDGSDTEMA SGSNRTPVFS FLDLTYWKRQ KICCGIIYKG
   181  RFGEVLIDTH LFKPCCSNKK AAAEKPEEQG PEPLPISTQE W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SINHCAF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

endometrium: 49 nTPM
thymus: 47 nTPM
fallopian tube: 34 nTPM
lymph node: 32 nTPM
urinary bladder: 32 nTPM
tonsil: 31 nTPM

Single-cell type

choroid plexus epithelial cells: 170 nCPM
early spermatids: 159 nCPM
renal collecting duct intercalated cells: 129 nCPM
fallopian secretory cells: 115 nCPM
fallopian tube ciliated cells: 114 nCPM
epididymal basal cells: 108 nCPM

Immune cell

plasmacytoid DC: 72 nTPM
memory B-cell: 59 nTPM
NK-cell: 51 nTPM
naive B-cell: 49 nTPM
naive CD4 T-cell: 36 nTPM
memory CD4 T-cell: 31 nTPM

Brain region

choroid plexus: 22 nTPM
cerebellum: 6.6 nTPM
medulla oblongata: 5.3 nTPM
basal ganglia: 5.1 nTPM
midbrain: 4.2 nTPM
spinal cord: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.96
DepMap mean gene effect: -0.48
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

SIN3-HDAC complex-associated factor
Protein Family FAM60A

KeywordsUniProt

Nucleus

InteractionsUniProt · HPA

Protein binding partners of SINHCAF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SINHCAF as an antibody target. Whether an autoantibody or antibody against SINHCAF could matter depends on whether native SINHCAF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SINHCAF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SINHCAF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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