Seroatlas · Human Serome Atlas

MXD4

Max dimerization protein 4

Also known as: bHLHc12, MAD4, MAD4_HUMAN, MST149, MSTP149

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14582
Gene: MXD4
Ensembl: ENSG00000123933
Chromosome: 4
Canonical length: 209 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Cytosol

OverviewNCBI Gene

This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

209 residues, UniProt reviewed canonical sequence.

>Q14582|MXD4
     1  MELNSLLILL EAAEYLERRD REAEHGYASV LPFDGDFARE KTKAAGLVRK APNNRSSHNE
    61  LEKHRRAKLR LYLEQLKQLV PLGPDSTRHT TLSLLKRAKV HIKKLEEQDR RALSIKEQLQ
   121  QEHRFLKRRL EQLSVQSVER VRTDSTGSAV STDDSEQEVD IEGMEFGPGE LDSVGSSSDA
   181  DDHYSLQSGT GGDSGFGPHC RRLGRPALS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MXD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 123 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 123 nTPM
pituitary gland: 66 nTPM
spleen: 58 nTPM
blood vessel: 49 nTPM
adrenal gland: 43 nTPM
cerebral cortex: 41 nTPM

Single-cell type

breast lactating cells: 128 nCPM
kupffer cells: 119 nCPM
pdcs: 117 nCPM
lactotrophs: 96 nCPM
epididymal principal cells: 96 nCPM
microglia: 94 nCPM

Immune cell

basophil: 7.2 nTPM
plasmacytoid DC: 7.2 nTPM
T-reg: 4 nTPM
eosinophil: 3.4 nTPM
gdT-cell: 3.4 nTPM
memory CD8 T-cell: 3.3 nTPM

Brain region

cerebellum: 86 nTPM
amygdala: 48 nTPM
cerebral cortex: 47 nTPM
thalamus: 44 nTPM
midbrain: 42 nTPM
medulla oblongata: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.78
gnomAD missense Z: 0.74
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MXD4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MXD4 as an antibody target. Whether an autoantibody or antibody against MXD4 could matter depends on whether native MXD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MXD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MXD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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