Seroatlas · Human Serome Atlas

SUDS3

Sin3 histone deacetylase corepressor complex component SDS3

Also known as: FLJ00052, SAP45, SDS3, SDS3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7L9
Gene: SUDS3
Ensembl: ENSG00000111707
Chromosome: 12
Canonical length: 328 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>Q9H7L9|SUDS3
     1  MSAAGLLAPA PAQAGAPPAP EYYPEEDEEL ESAEDDERSC RGRESDEDTE DASETDLAKH
    61  DEEDYVEMKE QMYQDKLASL KRQLQQLQEG TLQEYQKRMK KLDQQYKERI RNAELFLQLE
   121  TEQVERNYIK EKKAAVKEFE DKKVELKENL IAELEEKKKM IENEKLTMEL TGDSMEVKPI
   181  MTRKLRRRPN DPVPIPDKRR KPAPAQLNYL LTDEQIMEDL RTLNKLKSPK RPASPSSPEH
   241  LPATPAESPA QRFEARIEDG KLYYDKRWYH KSQAIYLESK DNQKLSCVIS SVGANEIWVR
   301  KTSDSTKMRI YLGQLQRGLF VIRRRSAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUDS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 24 nTPM
thyroid gland: 20 nTPM
esophagus: 20 nTPM
skin: 19 nTPM
tonsil: 18 nTPM
salivary gland: 18 nTPM

Single-cell type

oocytes: 327 nCPM
early spermatids: 269 nCPM
late primary spermatocytes: 202 nCPM
esophageal apical cells: 179 nCPM
esophageal suprabasal cells: 119 nCPM
respiratory ciliated cells: 108 nCPM

Immune cell

neutrophil: 13 nTPM
memory B-cell: 8.8 nTPM
naive B-cell: 8.4 nTPM
plasmacytoid DC: 6.8 nTPM
naive CD4 T-cell: 6.4 nTPM
MAIT T-cell: 6.1 nTPM

Brain region

cerebral cortex: 34 nTPM
midbrain: 33 nTPM
pons: 32 nTPM
basal ganglia: 30 nTPM
amygdala: 29 nTPM
hippocampal formation: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0
gnomAD missense Z: 1.94
DepMap mean gene effect: -0.73
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SUDS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUDS3 as an antibody target. Whether an autoantibody or antibody against SUDS3 could matter depends on whether native SUDS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUDS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUDS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...