TOX

Protein identityUniProt · HPA

UniProt accession

O94900

Gene

TOX

Ensembl

ENSG00000198846

Chromosome

8

Canonical length

526 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

526 residues, UniProt reviewed canonical sequence.

>O94900|TOX
     1  MDVRFYPPPA QPAAAPDAPC LGPSPCLDPY YCNKFDGENM YMSMTEPSQD YVPASQSYPG
    61  PSLESEDFNI PPITPPSLPD HSLVHLNEVE SGYHSLCHPM NHNGLLPFHP QNMDLPEITV
   121  SNMLGQDGTL LSNSISVMPD IRNPEGTQYS SHPQMAAMRP RGQPADIRQQ PGMMPHGQLT
   181  TINQSQLSAQ LGLNMGGSNV PHNSPSPPGS KSATPSPSSS VHEDEGDDTS KINGGEKRPA
   241  SDMGKKPKTP KKKKKKDPNE PQKPVSAYAL FFRDTQAAIK GQNPNATFGE VSKIVASMWD
   301  GLGEEQKQVY KKKTEAAKKE YLKQLAAYRA SLVSKSYSEP VDVKTSQPPQ LINSKPSVFH
   361  GPSQAHSALY LSSHYHQQPG MNPHLTAMHP SLPRNIAPKP NNQMPVTVSI ANMAVSPPPP
   421  LQISPPLHQH LNMQQHQPLT MQQPLGNQLP MQVQSALHSP TMQQGFTLQP DYQTIINPTS
   481  TAAQVVTQAM EYVRSGCRNP PPQPVDWNND YCSSGGMQRD KALYLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.66

Highest tissue expression

49 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.2

gnomAD pLI

1

gnomAD missense Z

1.2

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• CD4-positive, alpha-beta T cell lineage commitment
• CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
• CD8-positive, alpha-beta T cell lineage commitment
• cerebral cortex neuron differentiation
• chromatin organization
• leukocyte differentiation
• lymph node development
• natural killer cell differentiation
• Peyer's patch development
• positive regulation of natural killer cell differentiation
• positive regulation of neural precursor cell proliferation
• positive regulation of neuron projection development
• positive regulation of transcription by RNA polymerase II
• regulation of positive thymic T cell selection
• regulation of transcription by RNA polymerase II
• NK T cell lineage commitment

Molecular functions

• chromatin DNA binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• High mobility group box domain
• High mobility group box domain superfamily
• TOX high mobility group box domain-containing protein
• HMG (high mobility group) box

KeywordsUniProt

• Chromatin regulator
• DNA-binding
• Neurogenesis
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of TOX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DNMT1
• LEO1
• PAF1
• SAP130
• SIN3A