Seroatlas · Human Serome Atlas

SAP30L

Histone deacetylase complex subunit SAP30L

Also known as: FLJ11526, NS4ATP2, SP30L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HAJ7
Gene: SAP30L
Ensembl: ENSG00000164576
Chromosome: 5
Canonical length: 183 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Enables several functions, including non-sequence-specific DNA binding activity, bending; phosphatidylinositol phosphate binding activity; and zinc ion binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. Part of histone deacetylase complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>Q9HAJ7|SAP30L
     1  MNGFSTEEDS REGPPAAPAA AAPGYGQSCC LIEDGERCVR PAGNASFSKR VQKSISQKKL
    61  KLDIDKSVRH LYICDFHKNF IQSVRNKRKR KTSDDGGDSP EHDTDIPEVD LFQLQVNTLR
   121  RYKRHYKLQT RPGFNKAQLA ETVSRHFRNI PVNEKETLAY FIYMVKSNKS RLDQKSEGGK
   181  QLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAP30L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

ovary: 16 nTPM
tongue: 14 nTPM
colon: 14 nTPM
blood vessel: 14 nTPM
skeletal muscle: 14 nTPM
cervix: 13 nTPM

Single-cell type

neutrophils: 43 nCPM
enterocytes: 33 nCPM
retinal pigment epithelial cells: 30 nCPM
leydig cells: 29 nCPM
fallopian tube ciliated cells: 29 nCPM
salivary duct cells: 28 nCPM

Immune cell

NK-cell: 1.4 nTPM
non-classical monocyte: 1.2 nTPM
MAIT T-cell: 0.6 nTPM
memory CD4 T-cell: 0.6 nTPM
memory CD8 T-cell: 0.6 nTPM
naive CD4 T-cell: 0.6 nTPM

Brain region

spinal cord: 22 nTPM
white matter: 22 nTPM
basal ganglia: 21 nTPM
midbrain: 21 nTPM
thalamus: 21 nTPM
medulla oblongata: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.8
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAP30L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAP30L as an antibody target. Whether an autoantibody or antibody against SAP30L could matter depends on whether native SAP30L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAP30L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAP30L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...