Seroatlas · Human Serome Atlas

MXD3

Max dimerization protein 3

Also known as: bHLHc13, MAD3, MAD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BW11
Gene: MXD3
Ensembl: ENSG00000213347
Chromosome: 5
Canonical length: 206 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

206 residues, UniProt reviewed canonical sequence.

>Q9BW11|MXD3
     1  MEPLASNIQV LLQAAEFLER REREAEHGYA SLCPHRSPGP IHRRKKRPPQ APGAQDSGRS
    61  VHNELEKRRR AQLKRCLERL KQQMPLGADC ARYTTLSLLR RARMHIQKLE DQEQRARQLK
   121  ERLRSKQQSL QRQLEQLRGL AGAAERERLR ADSLDSSGLS SERSDSDQEE LEVDVESLVF
   181  GGEAELLRGF VAGQEHSYSH GGGAWL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MXD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 39 nTPM
spleen: 22 nTPM
liver: 16 nTPM
esophagus: 15 nTPM
thymus: 13 nTPM
pancreas: 13 nTPM

Single-cell type

epicardial cells: 86 nCPM
neutrophils: 76 nCPM
cardiomyocytes: 48 nCPM
plasma cells: 47 nCPM
neutrophil progenitors: 46 nCPM
enteric transient amplifying cells: 37 nCPM

Immune cell

neutrophil: 21 nTPM
non-classical monocyte: 13 nTPM
eosinophil: 13 nTPM
intermediate monocyte: 11 nTPM
naive B-cell: 4.4 nTPM
basophil: 4.1 nTPM

Brain region

white matter: 9.1 nTPM
cerebral cortex: 6.7 nTPM
medulla oblongata: 6.7 nTPM
thalamus: 6.6 nTPM
pons: 6.5 nTPM
choroid plexus: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0.19
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MXD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MXD3 as an antibody target. Whether an autoantibody or antibody against MXD3 could matter depends on whether native MXD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MXD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MXD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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